Human Leukocyte Antigens (HLA) Genes Association in Type 1 Diabetic Nephropathy

Author(s): Esma Mihoubi, Habiba Amroun, Rachida Raache*, Faiza Bouldjennet, Fethi Meçabih, Malha Azzouz, Aissa Boudiba, Souad Mahgoun, Malika Akachouche, Nawel Salhi, Chafia Touil-Boukoffa, Mohamed C. Abbadi, Nabila Attal

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders

Volume 19 , Issue 8 , 2019

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Graphical Abstract:


Background: Diabetic nephropathy is a common worldwide multifactorial disease where involvement of genetic factors is well etablished. The aim of this study was to investigate the HLA genes implication in the development of type 1 diabetic nephropathy.

Methods: We performed a case- control study where one hundred and fifty subjects were examined. Patients were divided in two groups; with and without type 1 diabetic nephropathy. HLA typing was performed using Polymerase Chain Reaction- Sequence Specific Oligonucleotide (PCR- SSO) method. HLA association to clinical phenotype and HLA haplotype analysis was also investigated.

Results: HLA B*51 is increased in patients without type 1 diabetic nephropathy (7.14% vs. 0 %, P <0.05, OR= 0), however no other studied alleles seem to have any effect (all P>0.05). Haplotype analysis also does not reveal any significant association, however, A*02-B*18-DRB1*03-DQA1*05- DQB1*03 haplotype shows a tendency to be associated with the development of diabetic nephropathy (P = 0.05).

Conclusion: These results suggest a protective effect of HLA B*51 allele from type 1 diabetic nephropathy. However, further studies are required in order to clarify its potential implication as a protective marker.

Keywords: Type 1diabetes, diabetic nephropathy, class I HLA genes, class II HLA genes, alleles, analysis, haplotype analysis.

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Year: 2019
Published on: 11 November, 2019
Page: [1157 - 1164]
Pages: 8
DOI: 10.2174/1871530319666190215143059
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