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Nanoscience & Nanotechnology-Asia

Editor-in-Chief

ISSN (Print): 2210-6812
ISSN (Online): 2210-6820

Research Article

CdSe Quantum Dots Induce Cellular Differentiation in HL-60 Cells

Author(s): Amit D. Saran* and Jayesh R. Bellare

Volume 10, Issue 2, 2020

Page: [175 - 183] Pages: 9

DOI: 10.2174/2210681209666190211160721

Price: $65

Abstract

Background: CdSe QDs, synthesized using a green micro-emulsion method, have been evaluated for their potential in inducing HL-60 differentiation by employing various biochemical assays and as cellular imaging agents.

Methods: CdSe QDs have been found to effectively induce differentiation with lower rate of cell apoptosis as compared with the positive control (DMSO).

Results: Our results exhibit effective induction of HL-60 differentiation by CdSe QDs implicating their therapeutic role in cancerous cells in addition to their usual application as cell-imaging agents.

Conclusion: Our studies report that the chemo-preventive properties of CdSe exhibit great potential and further tailored-synthesis and cell-differen-tiations studies have a promising future in the preventive treatment of HL60 cancerous tissue.

Keywords: CdSe, quantum dots, microemulsion, HL60, cell differentiation, cell death, nanomedicine.

Graphical Abstract
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