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Current Aging Science

Editor-in-Chief

ISSN (Print): 1874-6098
ISSN (Online): 1874-6128

Research Article

The Effects of Healthy Ageing on Cerebral Blood Flow Responses to Cognitive Testing

Author(s): Lucy Beishon*, Jatinder S. Minhas, Kate Patrick, Iswariya Shanmugam, Claire A.L. Williams, Ronney B. Panerai, Thompson G. Robinson and Victoria J. Haunton

Volume 11, Issue 4, 2018

Page: [226 - 235] Pages: 10

DOI: 10.2174/1874609812666190131165310

Abstract

Background: Transcranial Doppler Ultrasonography (TCD) can be utilised to measure the tight coupling of cerebral blood flow velocity (CBFv) in response to cognitive demand by task activation, termed neurovascular coupling.

Aims: To investigate the differences in neurovascular coupling between healthy older (>50 years) and younger (18-49 years) adults in response to cognitive testing.

Methods: Fifty-four older (n=25) and younger (n=29) adults underwent continuous bilateral TCD, beat-to-beat blood pressure (MAP; Finapres), heart rate (HR; electrocardiogram), and end-tidal CO2 (ETCO2; capnography) monitoring. After a 5-min baseline period, memory (M1-4: recalling three learned words, learning a name and address, recalling US presidents and UK prime ministers, and recalling the previously learned name and address) and visuospatial (V1-4: drawing a cube and infinity diagram, drawing a clock face, counting dots, and recognising obscured letters) tasks from the Addenbrooke's Cognitive Examination (ACE-III) were performed. Data are mean (standard deviation).

Results: In the memory paradigms, the peak percentage change in CBFv differed significantly between younger and older groups only in the dominant hemisphere during the M1 task, (2.17 (9.16)% vs. 8.38 (9.27)%, respectively, p=0.017). In the visuospatial paradigm, there were also significant differences in peak percentage change in CBFv between younger and older groups in the V1 (5.87 (8.32)% vs. 11.89 (6.60)%, p=0.005) and V2 tasks (6.30 (8.72)% vs. 11.30 (7.77)%, p=0.032).

Conclusion: Healthy older adults demonstrate augmented cerebrovascular physiology in response to cognitive challenge compared to younger adults. The impact of abnormal ageing on cerebrovascular physiology, for example, related to cognitively impaired states, requires further investigation.

Keywords: Addenbrooke's cognitive examination, transcranial doppler ultrasonography, neurovascular coupling, healthy ageing, cerebral blood flow, functional imaging.

Graphical Abstract
[1]
Organisation WH. Ageing and Health 2015 [cited 2018 23/03/2018] Available from: http://www.who.int/mediacentre/factsheets/fs404/en/
[2]
Prince M, Wimo A, Guerchet M, et al. World Alzheimer Report 2015 The global impact of dementia Alzheimer's Disease International. 2015 Contract No.: Report.
[3]
Rebok GW, Ball K, Guey LT, et al. Ten-year effects of the ACTIVE cognitive training trial on cognition and everyday functioning in older adults. J Am Geriatr Soc 2014; 62(1): 16-24.
[4]
Keage HA, Churches OF, Kohler M, et al. Cerebrovascular function in aging and dementia: A systematic review of transcranial Doppler studies. Dement Geriatr Cogn Disord Extra 2012; 2(1): 258-70.
[5]
Sabayan B, Jansen S, Oleksik AM, et al. Cerebrovascular hemodynamics in Alzheimer’s disease and vascular dementia: A meta-analysis of transcranial Doppler studies. Ageing Res Rev 2012; 11(2): 271-7.
[6]
Wierenga CE, Hays CC, Zlatar ZZ. Cerebral blood flow measured by arterial spin labeling MRI as a preclinical marker of Alzheimer’s disease. J Alzheimers Dis 2014; 42(Suppl. 4): S411-9.
[7]
Hays CC, Zlatar ZZ, Wierenga CE. The utility of cerebral blood flow as a biomarker of preclinical Alzheimer’s disease. Cell Mol Neurobiol 2016; 36(2): 167-79.
[8]
Wolters FJ, Zonneveld HI, Hofman A, et al. Cerebral perfusion and the risk of dementia: A population-based study. Circulation 2017; 136(8): 719-28.
[9]
Van Beek AH, Claassen JA, Rikkert MG, et al. Cerebral autoregulation: An overview of current concepts and methodology with special focus on the elderly. J Cereb Blood Flow Metab 2008; 28(6): 1071-85.
[10]
Panerai RB. Transcranial doppler for evaluation of cerebral autoregulation. Clin Auton Res 2009; 19(4): 197-211.
[11]
Beishon LC, Williams CAL, Panerai RB, et al. The assessment of neurovascular coupling with the Addenbrooke’s cognitive examination: A functional transcranial doppler ultrasonographic study. J Neurophysiol 2018; 119(3): 1084-94.
[12]
Beishon L, Williams CAL, Panerai RB, et al. Reproducibility of task activation using the Addenbrooke’s cognitive examination in healthy controls: A functional transcranial doppler ultrasonography study. J Neurosci Methods 2017; 291: 131-40.
[13]
Williams CAL, Panerai RB, Robinson TG, et al. Transcranial doppler ultrasonography in the assessment of neurovascular coupling responses to cognitive examination in healthy controls: A feasibility study. J Neurosci Methods 2017; 284: 57-62.
[14]
Harwood AE, Greenwood PM, Shaw TH. Transcranial doppler sonography reveals reductions in hemispheric asymmetry in healthy older adults during vigilance. Front Aging Neurosci 2017; 9: 21.
[15]
Berlingeri M, Danelli L, Bottini G, et al. Reassessing the HAROLD model: Is the hemispheric asymmetry reduction in older adults a special case of compensatory-related utilisation of neural circuits? Exp Brain Res 2013; 224(3): 393-410.
[16]
Sorond FA, Schnyer DM, Serrador JM, et al. Cerebral blood flow regulation during cognitive tasks: Effects of healthy aging. Cortex 2008; 44(2): 179-84.
[17]
Mioshi E, Dawson K, Mitchell J, et al. The Addenbrooke’s Cognitive Examination Revised (ACE-R): A brief cognitive test battery for dementia screening. Int J Geriatr Psychiatry 2006; 21(11): 1078-85.
[18]
Velayudhan L, Ryu SH, Raczek M, et al. Review of brief cognitive tests for patients with suspected dementia. Int Psychogeriatr 2014; 26(8): 1247-62.
[19]
Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004; 256(3): 183-94.
[20]
Iachini I, Iavarone A, Senese VP, et al. Visuospatial memory in healthy elderly, AD and MCI: A review. Curr Aging Sci 2009; 2(1): 43-59.
[21]
Oldfield RC. The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia 1971; 9(1): 97-113.
[22]
Cabeza R. Hemispheric asymmetry reduction in older adults: The HAROLD model. Psychol Aging 2002; 17(1): 85-100.
[23]
Beishon L, Haunton VJ, Panerai RB, et al. Cerebral hemodynamics in mild cognitive impairment: A systematic review. J Alzheimers Dis 2017; 59(1): 369-85.
[24]
Wierenga CE, Bondi MW. Use of functional magnetic resonance imaging in the early identification of Alzheimer’s disease. Neuropsychol Rev 2007; 17(2): 127-43.
[25]
Stroobant N, Vingerhoets G. Transcranial Doppler ultrasonography monitoring of cerebral hemodynamics during performance of cognitive tasks: A review. Neuropsychol Rev 2000; 10(4): 213-31.
[26]
Logan JM, Sanders AL, Snyder AZ, et al. Under-recruitment and nonselective recruitment: Dissociable neural mechanisms associated with aging. Neuron 2002; 33(5): 827-40.
[27]
Cabeza R, Grady CL, Nyberg L, et al. Age-related differences in neural activity during memory encoding and retrieval: A positron emission tomography study. J Neurosci 1997; 17(1): 391-400.
[28]
Reuter-Lorenz PA, Jonides J, Smith EE, et al. Age differences in the frontal lateralization of verbal and spatial working memory revealed by PET. J Cogn Neurosci 2000; 12(1): 174-87.
[29]
Grady CL, Maisog JM, Horwitz B, et al. Age-related changes in cortical blood flow activation during visual processing of faces and location. J Neurosci 1994; 14(3 Pt 2): 1450-62.
[30]
Szaflarski JP, Binder JR, Possing ET, et al. Language lateralization in left-handed and ambidextrous people: fMRI data. Neurology 2002; 59(2): 238-44.

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