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Current Pharmaceutical Analysis

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ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

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Review Article

Recent Trends in Chiral Separation-A Collective Paradigm of Selected Chiral Impurities

Author(s): Prachi Raikar and Gurupadayya Bannimath*

Volume 16, Issue 5, 2020

Page: [456 - 473] Pages: 18

DOI: 10.2174/1573412915666181219144507

Price: $65

Abstract

Chiral separation plays a very important role in the modern pharmaceutical analysis and will continue in upcoming years. Separation and identification of chiral impurities are indispensable. According to ICH guidelines, only the active enantiomer of the drug has to be marketed, so there is a focus on separation of the inactive enantiomer which acts as a chiral impurity. The impurities present in the enantiomers also pose various toxic adverse effects on bioavailability and efficacy, hence the need to separate these impurities will forever be trending. This review primarily focuses on the separation techniques like Capillary Electrophoresis (CE), High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), and Supercritical Fluid Chromatography (SFC) followed by the year-wise trend in the separation of selected chiral impurities. In the coming years, researchers should work on using ultra-fast, selective, and sensitive methods for the effective separation of chiral impurities.

Keywords: Capillary Electrophoresis (CE), chiral impurities, chirality, Chiral Stationary Phase (CSP), enantiomers, High- Performance Liquid Chromatography (HPLC).

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