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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Review Article

Virtual Screening of Natural Products to Select Compounds with Potential Anticancer Activity

Author(s): Élida B.V.S. Cavalcanti, Mayara B. Félix, Luciana Scotti and Marcus T. Scotti*

Volume 19, Issue 2, 2019

Page: [154 - 171] Pages: 18

DOI: 10.2174/1871520618666181119110934

Price: $65

Abstract

Cancer is the main cause of death, so the search for active agents to be used in the therapy of this disease, is necessary. According to studies conducted, substances derived from natural products have shown to be promising in this endeavor. To these researches, one can associate with the aid of computational chemistry, which is increasingly gaining popularity, due to the possibility of developing alternative strategies that could help in choosing an appropriate set of compounds, avoiding unnecessary expenses with resources that would generate unwanted substance. Thus, the objective of this study was to carry out an approach to several studies that apply different methods of virtual screening to select natural products with potential anticancer activity. This review presents reports of studies conducted with some natural products, such as coumarin, quinone, tannins, alkaloids, flavonoids and terpenes.

Keywords: Cancer, natural products, virtual screening, secondary metabolites, potential anticancer activity, computational chemistry.

Graphical Abstract
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