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Nanoscience & Nanotechnology-Asia

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ISSN (Print): 2210-6812
ISSN (Online): 2210-6820

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Research Article

Optimization of Itroconazole Solid Lipid Nanoparticles for Topical Delivery

Author(s): Pallavi M. Chaudhari* and Amruta R. Patil

Volume 10, Issue 4, 2020

Page: [381 - 389] Pages: 9

DOI: 10.2174/2210681208666181112142717

Price: $65

Abstract

Introduction: The objective of this study was to formulate water-insoluble drug Itraconazole (ITZ) into Solid Lipid Nanoparticles (SLNs) for topical delivery.

Methods: The drug-loaded SLNs were prepared by Microemulsion method using cholesterol (CH) and Lubritab (LU) and further characterized for different parameters like particle size, zeta potential, drug entrapment efficiency etc. The mean particle size with Lubritab SLN was in the range 155.01-161.67 nm, whereas for Cholestrol SLN it was in the range of 218.87-230.16 nm. SEM showed spherical nature of the SLNs.

Results: The entrapment efficiency of SLN was found to be more for cholesterol as compared to Lubritab. The crystalline properties of drug was reduced in SLNs as evaluated by X-ray diffraction (XRD). Ex vivo study indicated the ITZ-SLN exhibited high concentration.

Conclusion: The permeability of drug was studied by use of Franz-diffusion cell, and permeation of drug through Lubritab SLN (ITZ LU) was higher than that of Cholesterol SLN (ITZ CH). The formulated ITZ-SLNs exhibited clear zone.

Keywords: Itroconazle, solid lipid nanoparticles, optimization and entrapment efficiency, permeability, cholesterol, antifungal agents.

Graphical Abstract

[1]
Trombino, S.; Mellace, S.; Cassano, R. Solid lipid nanoparticles for antifungal drugs delivery for topical applications. Ther. Deliv., 2016, 7(9), 639-647.
[2]
Yadav, N.; Khatak, S. Solid Lipid Nanoparticles – A Review. Int. J. Appl. Pharmaceut., 2013, 5(2), 818.
[3]
Kadam, S.; Chavan, M. Solid Lipid Nanoparticles: A lipid based Drug delivery. Innovat. Pharmaceut. Pharmacother., 2014, 2(3), 367.
[4]
Mohanty, B.; Majumdar, D.; Mishra, S.; Panda, A.; Patnaik, S. Development and characterization of itraconazole-loaded solid lipid nanoparticles for ocular delivery. Pharm. Dev. Technol., 2014, 20(4), 458-464.
[5]
Reddy, K.; Vandana, P.; Mani, D.; Audinarayana, N.; Mohanambal, E.; Kumaravelrajan, R.; Sundaram, M. Formulation and in vitro assessment of itraconazole loaded solid lipid nanoparticles for topical delivery. Int. J. Adv. Biomed. Pharm. Res., 2012, 1(1), 1-10.
[6]
Shah, R.; Malherbe, F. Physicochemical characterization of solid lipid nanoparticles (SLNs) prepared by a novel microemulsion technique. J. Colloid Interface Sci., 2014, 428, 286-294.
[7]
Khare, A.; Singh, I.; Pawar, P.; Grover, K. Design and evaluation of voriconazole loaded solid lipid nanoparticles for ophthalmic application. J. Drug Deliv., 2016, 2016, 6590361
[8]
Patel, N.; Padia, N. Formulation and Evaluation of microsponge gel for topical delivery of fluconazole for fungal therapy. J. Pharm. Investig., 2016, 46, 221-238.
[9]
Lim, W.; Rajinikanth, P. Formulation and delivery of Itraconazole to the brain using a nanolipid carrier system. Int. J. Nanomedicine, 2014, 9(1), 2117-2126.
[10]
Alsarra, A.; Bayomil, M. Optimization of 5-flurouracil solid-lipid nanoparticles: a preliminary study to treat colon cancer. Int. J. Med. Sci., 2010, 7(6), 398-408.
[11]
Singhvi, G.; Singh, M. In-vitro drug release characterization models. Int. J. Pharmaceut. Studies Res., 2011, 2(1), 77-84.

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