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Review Article

Aryl Hydrocarbon Receptor: Its Regulation and Roles in Transformation and Tumorigenesis

Author(s): Xun Che and Wei Dai*

Volume 20, Issue 6, 2019

Page: [625 - 634] Pages: 10

DOI: 10.2174/1389450120666181109092225

Price: $65

Abstract

AhR is an environmental response gene that mediates cellular responses to a variety of xenobiotic compounds that frequently function as AhR ligands. Many AhR ligands are classified as carcinogens or pro-carcinogens. Thus, AhR itself acts as a major mediator of the carcinogenic effect of many xenobiotics in vivo. In this concise review, mechanisms by which AhR trans-activates downstream target gene expression, modulates immune responses, and mediates malignant transformation and tumor development are discussed. Moreover, activation of AhR by post-translational modifications and crosstalk with other transcription factors or signaling pathways are also summarized.

Keywords: Aryl hydrocarbon receptor, xenobiotics, carcinogenesis, transcription factor, post-translation modification, review.

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