[1]
Russell, J.P.; Gibson, L.E. Primary cutaneous small vessel vasculitis: Approach to diagnosis and treatment. Int. J. Dermatol., 2006, 45(1), 3-13.
[2]
Gyselbrecht, L.; De Keyser, F.; Ongenae, K.; Naeyaert, J.M.; Praet, M.; Veys, E.M. Etiological factors and underlying conditions in patients with leucocytoclastic vasculitis. Clin. Exp. Rheumatol., 1996, 14(6), 665-668.
[3]
Drago, F.; Rampini, P.; Brusati, C.; Rebora, A. Leukocytoclastic vasculitis in a patient with HHV-6 infection. Acta Derm. Venereol., 2000, 80(1), 68.
[4]
Hashimoto, H.; Maruyama, H.; Fujimoto, K.; Sakakura, T.; Seishu, S.; Okuda, N. Hematologic findings associated with thrombocytopenia during the acute phase of exanthem subitum confirmed by primary human herpesvirus-6 infection. J. Pediatr. Hematol. Oncol., 2002, 24(3), 211-214.
[5]
Miura, H.; Kawamura, Y.; Ozeki, E.; Ihira, M.; Ohashi, M.; Yoshikawa, T. Pathogenesis of severe neutropenia in patients with primary human herpesvirus 6B infection. Pediatr. Infect. Dis. J., 2015, 34(9), 1003-1007.
[6]
Drago, F.; Broccolo, F.; Javor, S.; Drago, F.; Rebora, A.; Parodi, A. Evidence of human herpesvirus-6 and -7 reactivation in miscarrying women with pityriasis rosea. J. Am. Acad. Dermatol., 2014, 71(1), 198-199.
[7]
Pritchett, J.C.; Nanau, R.M.; Neuman, M.G. The link between hypersensitivity syndrome reaction development and human herpes virus-6 reactivation. Int. J. Hepatol., 2012, 2012, 723062.
[8]
Tohyama, M.; Hashimoto, K.; Yasukawa, M.; Kimura, H.; Horikawa, T.; Nakajima, K.; Urano, Y.; Matsumoto, K.; Iijima, M.; Shear, N.H. Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome. Br. J. Dermatol., 2007, 157(5), 934-940.
[9]
Miyagawa, F.; Nakamura, Y.; Miyashita, K.; Iioka, H.; Himuro, Y.; Ogawa, K.; Nishimura, C.; Nishikawa, M.; Mitsui, Y.; Ito, Y.; Ommori, R.; Mori, Y.; Asada, H. Preferential expression of CD134, an HHV-6 cellular receptor, on CD4T cells in drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS). J. Dermatol. Sci., 2016, 83(2), 151-154.
[10]
Pellett, P.E.; Ablashi, D.V.; Ambros, P.F.; Agut, H.; Caserta, M.T.; Descamps, V.; Flamand, L.; Gautheret-Dejean, A.; Hall, C.B.; Kamble, R.T.; Kuehl, U.; Lassner, D.; Lautenschlager, I.; Loomis, K.S.; Luppi, M.; Lusso, P.; Medveczky, P.G.; Montoya, J.G.; Mori, Y.; Ogata, M.; Pritchett, J.C.; Rogez, S.; Seto, E.; Ward, K.N.; Yoshikawa, T. Razonable, R.R. Chromosomally integrated human herpesvirus 6: Questions and answers. Rev. Med. Virol., 2012, 22(3), 144-155.
[11]
Ward, K.N.; Leong, H.N.; Nacheva, E.P.; Howard, J.; Atkinson, C.E.; Davies, N.W.; Griffiths, P.D.; Clark, D.A. Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles. J. Clin. Microbiol., 2006, 44(4), 1571-1574.
[12]
Ablashi, D.; Agut, H.; Alvarez-Lafuente, R.; Clark, D.A.; Dewhurst, S.; DiLuca, D.; Flamand, L.; Frenkel, N.; Gallo, R.; Gompels, U.A.; Höllsberg, P.; Jacobson, S.; Luppi, M.; Lusso, P.; Malnati, M.; Medveczky, P.; Mori, Y.; Pellett, P.E.; Pritchett, J.C.; Yamanishi, K.; Yoshikawa, T. Classification of HHV-6A and HHV-6B as distinct viruses. Arch. Virol., 2014, 159(5), 863-870.
[13]
Arbuckle, J.H.; Medveczky, P.G. The molecular biology of human herpesvirus-6 latency and telomere integration. Microbes Infect., 2011, 13(8-9), 731-741.
[14]
Arbuckle, J.H.; Medveczky, M.M.; Luka, J.; Hadley, S.H.; Luegmayr, A.; Ablashi, D.; Lund, T.C.; Tolar, J.; Meirleir, K.D.; Montoya, J.G.; Komaroff, A.L.; Ambros, P.F.; Medveczky, P.G. The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro. Proc. Natl. Acad. Sci. USA, 2010, 107(12), 5563-5568.
[15]
Zhang, E.; Bell, A.J.; Wilkie, G.S.; Suárez, N.M.; Batini, C.; Veal, C.D.; Armendáriz-Castillo, I.; Neumann, R.; Cotton, V.E.; Huang, Y.; Porteous, D.J.; Jarrett, R.F.; Davison, A.J.; Royle, N.J. Inherited chromosomally integrated human herpesvirus 6 genomes are ancient, intact and potentially able to reactivate from telomeres.J.
Virol., 2017, 91(22), pii: e01137-e01117,
[16]
Endo, A.; Watanabe, K.; Ohye, T.; Suzuki, K.; Matsubara, T.; Shimizu, N.; Kurahashi, H.; Yoshikawa, T.; Katano, H.; Inoue, N.; Imai, K.; Takagi, M.; Morio, T.; Mizutani, S. Molecular and virological evidence of viral activation from chromosomally integrated human Herpesvirus 6A in a patient with X-linked severe combined immunodeficiency. Clin. Infect. Dis., 2014, 59(4), 545-548.
[17]
Moustafa, A.; Xie, C.; Kirkness, E.; Biggs, W.; Wong, E.; Turpaz, Y.; Bloom, K.; Delwart, E.; Nelson, K.E.; Venter, J.C.; Telenti, A. The blood DNA virome in 8,000 humans. PLoS Pathog., 2017, 13(3), e1006292.
[18]
Hall, C.B.; Caserta, M.T.; Schnabel, K.C.; Shelley, L.M.; Carnahan, J.A.; Marino, A.S.; Yoo, C.; Lofthus, G.K. Transplacental human herpesvirus 6 (hhv-6) congenital infection caused by maternal chromosomally integrated virus. J. Infect. Dis., 2010, 201(4), 505-507.
[19]
Gravel, A.; Hall, C.B.; Flamand, L. Sequence analysis of transplacentally acquired human herpesvirus 6 DNA is consistent with transmission of a chromosomally integrated reactivated virus. J. Infect. Dis., 2013, 207(10), 1585-1589.
[20]
Gravel, A.; Dubuc, I.; Morissette, G.; Sedlak, R.H.; Jerome, K.R.; Flamand, L. Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris. Proc. Natl. Acad. Sci. USA, 2015, 112(26), 8058-8063.
[21]
Hill, J.A.; Magaret, A.S.; Hall-Sedlak, R.; Mikhaylova, A.; Huang, M.L.; Sandmaier, B.M.; Hansen, J.A.; Jerome, K.R.; Zerr, D.M.; Boeckh, M. Outcomes of hematopoietic cell transplantation using donors or recipients with inherited chromosomally integrated HHV-6. Blood, 2017, 130(8), 1062-1069.
[22]
Hill, J.A.; Mayer, B.T.; Xie, H.; Leisenring, W.M.; Huang, M.L.; Stevens-Ayers, T.; Milano, F.; Delaney, C.; Sorror, M.L.; Sandmaier, B.M.; Nichols, G.; Zerr, D.M.; Jerome, K.R.; Schiffer, J.T.; Boeckh, M. The cumulative burden of double-stranded DNA virus detection after allogeneic HCT is associated with increased mortality. Blood, 2017, 129(16), 2316-2325.
[23]
Hall, C.B.; Long, C.E.; Schnabel, K.C.; Caserta, M.T.; McIntyre, K.M.; Costanzo, M.A.; Knott, A.; Dewhurst, S.; Insel, R.A.; Epstein, L.G. Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. N. Engl. J. Med., 1994, 331(7), 432-438.
[24]
Epstein, L.G.; Shinnar, S.; Hesdorffer, D.C.; Nordli, D.R.; Hamidullah, A.; Benn, E.K.; Pellock, J.M.; Frank, L.M.; Lewis, D.V.; Moshe, S.L.; Shinnar, R.C.; Sun, S. Human herpesvirus 6 and 7 in febrile status epilepticus: The febstat study. Epileps, 2012, 53(9), 1481-1488.
[25]
Caselli, E.; Zatelli, M.C.; Rizzo, R.; Benedetti, S.; Martorelli, D.; Trasforini, G.; Cassai, E.; Uberti, E.C.; Luca, D.D.; Dolcetti, R. Virologic and immunologic evidence supporting an association between HHV-6 and Hashimoto’s thyroiditis. PLoS Pathog., 2012, 8(10), e1002951.
[26]
Marci, R.; Gentili, V.; Bortolotti, D.; Lo Monte, G.; Caselli, E.; Bolzani, S.; Rotola, A.; Luca, D.D.; Rizzo, R. Presence of HHV-6A in endometrial epithelial cells from women with primary unexplained infertility. PLoS One, 2016, 11(7), e0158304.
[27]
Cone, R.W.; Huang, M.L.; Hackman, R.C.; Corey, L. Coinfection with human herpesvirus 6 variants A and B in lung tissue. J. Clin. Microbiol., 1996, 34(4), 877-881.
[28]
Bajric, J.; Smith, W.M. A case of bilateral human herpes virus 6 panuveitis with genomic viral DNA integration. J. Ophthalmic Inflamm. Infect., 2014, 4-16.
[29]
Dagna, L.; Pritchett, J.C.; Lusso, P. Immunomodulation and immunosuppression by human herpesvirus 6A and 6B. Future Virol., 2013, 8(3), 273-287.
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