Abstract
Pain affects approximately 30% of people and places a large economic and social burden on society. Despite the availability of a range of analgesics, complete alleviation of symptoms still rarely occurred. Effective and safe drugs for the treatment of pain are still an unmet clinical need. In recent years, the voltage-gated sodium channels (VGSCs) have been recognized as potential targets for analgesic development. VGSCs are major players in generating and propagating action potentials. They represent an appealing target for the development of new and safer drugs in the treatment of pain. The majority of the research has been focused on Nav1.7 in particular, other VGSC subtypes, such as Nav1.1, Nav1.3, Nav1.6, Nav1.8 and Nav1.9 have recently come to the forefront of analgesic research. Peptides from scorpion have been proved to be a valuable tool in neuroscience, playing a significant role in the identification and characterization of VGSC subtypes and many of them resulting in analgesia in pain. This review assesses the potential of scorpion toxin targeting VGSCs for analgesic development.
Keywords: Pain, VGSC, peptide, scorpion toxin, autoimmune diseases, NSAIDs.
Current Pharmaceutical Biotechnology
Title:Scorpion Toxins Targeting Voltage-gated Sodium Channels Associated with Pain
Volume: 19 Issue: 11
Author(s): Yijia Xu, Junxin Sun, Hongyu Liu, Jianfang Sun, Yue Yu, Yang Su, Yong Cui, Mingyi Zhao* Jinghai Zhang*
Affiliation:
- School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN,China
- School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, CN,China
Keywords: Pain, VGSC, peptide, scorpion toxin, autoimmune diseases, NSAIDs.
Abstract: Pain affects approximately 30% of people and places a large economic and social burden on society. Despite the availability of a range of analgesics, complete alleviation of symptoms still rarely occurred. Effective and safe drugs for the treatment of pain are still an unmet clinical need. In recent years, the voltage-gated sodium channels (VGSCs) have been recognized as potential targets for analgesic development. VGSCs are major players in generating and propagating action potentials. They represent an appealing target for the development of new and safer drugs in the treatment of pain. The majority of the research has been focused on Nav1.7 in particular, other VGSC subtypes, such as Nav1.1, Nav1.3, Nav1.6, Nav1.8 and Nav1.9 have recently come to the forefront of analgesic research. Peptides from scorpion have been proved to be a valuable tool in neuroscience, playing a significant role in the identification and characterization of VGSC subtypes and many of them resulting in analgesia in pain. This review assesses the potential of scorpion toxin targeting VGSCs for analgesic development.
Export Options
About this article
Cite this article as:
Xu Yijia , Sun Junxin , Liu Hongyu , Sun Jianfang , Yu Yue , Su Yang , Cui Yong , Zhao Mingyi *, Zhang Jinghai *, Scorpion Toxins Targeting Voltage-gated Sodium Channels Associated with Pain, Current Pharmaceutical Biotechnology 2018; 19 (11) . https://dx.doi.org/10.2174/1389201019666181105160744
DOI https://dx.doi.org/10.2174/1389201019666181105160744 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Oxidative Stress and Antioxidant Potential of One Hundred Medicinal Plants
Current Topics in Medicinal Chemistry Thrombosis and Nephrotic Syndrome in Children
Current Pediatric Reviews Reconstituted High Density Lipoprotein-Based Nanoparticles: an Overview of Applications in Regenerative Medicine, Preparation, Evaluation and Future Trends
Current Pharmaceutical Design Mood Stabilizers, Oxidative Stress and Antioxidative Defense in Euthymia of Bipolar Disorder
CNS & Neurological Disorders - Drug Targets Common Environmental Factors May Underpin the Comorbidity Between Generalized Anxiety Disorder and Mood Disorders Via Activated Nitrooxidative Pathways
Current Topics in Medicinal Chemistry The Association of Microglial Activation and Amyloid Reduction in APP+PS1 Transgenic Mice
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Animal Models of Ejaculatory Behavior
Current Pharmaceutical Design Scopolamine and Depression: A Role for Muscarinic Antagonism?
CNS & Neurological Disorders - Drug Targets Structural and Computational Biology of the Molecular Chaperone Hsp90: From Understanding Molecular Mechanisms to Computer-Based Inhibitor Design
Current Topics in Medicinal Chemistry Statistical Analysis, Optimization, and Prioritization of Virtual Screening Parameters for Zinc Enzymes Including the Anthrax Toxin Lethal Factor
Current Topics in Medicinal Chemistry Update on the Important New Drug Target in Cardiovascular Medicine – the Vascular Glycocalyx
Cardiovascular & Hematological Disorders-Drug Targets Neurodegeneration in Amygdala Precedes Hippocampus in the APPswe/ PS1dE9 Mouse Model of Alzheimer’s Disease
Current Alzheimer Research Health Anxiety (Hypochondriasis): an Emotional Disorder in An Alternative Taxonomy
Current Psychiatry Reviews Progress of HDAC Inhibitor Panobinostat in the Treatment of Cancer
Current Drug Targets NMR-based Metabolite Profiling of Pancreatic Cancer
Current Metabolomics Stimulant-Related Psychosis in ADHD Treatment: An Update for Past 10 Years
Current Psychopharmacology Marginal Vitamin A Deficiency Exacerbates Memory Deficits Following Aβ1-42 Injection in Rats
Current Alzheimer Research What Animal Models Have Taught us About Adenosine Receptor Function
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Bipolar Depression: The Neglected Realm of Postpartum Disorders
Current Psychiatry Reviews Breast Cancer Risks in Premenopausal Women: A Review
Current Women`s Health Reviews