Background: Salicylic acid (SA), used as an important component in a lot of skin care
products, has been reported widely. And because of large specific surface area, high porosity and good
surfactivity, electrospun drug-loaded nanofibers have been widely used in various applications including
wound dressing, tissue engineering and drug release. Particularly, the electrospun SA loaded porous
nanofibers could be fabricated by regulating electrospinning (ES) parameters, and the release
property of SA from nanofibers could be improved by the porous structure. Few relevant patents to the
topic have been reviewed and cited.
Methods: Electrospun polylactic acid (PLA) porous nanofibers with different contents of SA were prepared
successfully by modulating the ES parameters. The morphology and structure of the electrospun
SA/PLA porous nanofibers were characterized by scanning electron microscopy (SEM) and flourier
transformation infrared spectroscopy (FTIR). And the cumulative drug release rates of SA from
SA/PLA porous nanofibers were measured using ultraviolet spectrophotometer (UV).
Results: The PLA concentration of 8 wt%, the SA concentrations of 4, 8, 12 wt% and the applied voltage
of 15kv were selected as the optimal ES parameters. And the release percentage of low SA content
was higher than that of high SA content, and the porous nanofibers had a higher cumulative release
percentage of SA than the nonporous nanofibers.
Conclusion: The release property of SA from nanofibers could be improved by the porous structure. It
will provide a continuous and effective method for treating wounds.