Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Using Carboxylic Acids as Catalyst

Title:Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Using Carboxylic Acids as Catalyst

Volume: 7 Issue: 3

Author(s): Elham Mir, Ebrahim Mollashahi and Ghasem Marandi*

Affiliation:

• Department of Organic Chemistry, Faculty of Chemistry, Urmia University, Urmia,Iran

Keywords: Aromatic aldehydes, 2-aminobenzamide, carboxylic acids, 2, 3-dihydroquinazolin-4(1H)-one derivatives, benzilic acid, salicylic acid.

Abstract: Introduction: A one-pot approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in the reaction between 2-aminobezamide and aromatic aldehydes in the presence of highly available carboxylic acids such as benzilic acid, phthalic acid and salicylic acid has been reported.

Material and Methods: Carboxylic acids such as benzilic acid, phthalic acid and salicylic acid, used as efficient catalysts for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones, are structurally stable compounds. Synthesized compounds were characterized by 1H NMR and IR spectroscopy and their melting points are in good agreement with previous reports.

Results: Results show that carboxylic acids such as benzilic acid, phthalic acid and salicylic can act as effective catalysts in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones without any side products in acceptable reaction time.

Conclusion: In conclusion, we use a simple one-pot process for the synthesis of 2,3- dihydroquinazolin-4(1H)-ones by using carboxylic acids which has some advantages such as low cost, nontoxic solvents and simple separation of products.

Cite this article as:

Mir Elham, Mollashahi Ebrahim and Marandi Ghasem*, Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Using Carboxylic Acids as Catalyst, Current Catalysis 2018; 7 (3) . https://dx.doi.org/10.2174/2211544707666180924125826