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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Research Article

An Efficient Ligandless Palladium-catalyzed Protocol for Suzuki-Miyaura Coupling Reaction of Potassium Aryltrifluoroborates in Water

Author(s): Leifang Liu*, Mingcheng Liu, Jianhua Yang, Baoyong Zhu and Xinfang Wang*

Volume 22, Issue 20, 2018

Page: [2023 - 2028] Pages: 6

DOI: 10.2174/1385272822666180913110957

Price: $65

Abstract

An efficient and ligandless catalytic system was developed for the Suzuki- Miyaura coupling reactions of potassium aryltrifluoroborates in pure water. Using TEAB as additives, Pd(OAc)2 was found to be very efficient for the Suzuki-Miyaura coupling of potassium aryltrifluoroborates with various aryl and heteroaryl bromides in pure water with Na2CO3 as a base, affording the desired products in moderate to excellent yields.

Keywords: Suzuki-Miyaura coupling reaction, potassium aryltrifluoroborate, aryl bromide, heteroaryl bromide, water, palladium acetate.

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