LADA: A Type of Diabetes in its Own Right?

Valdemar       Grill

Abstract

Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than “classical” type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis have been challenged. Despite the absence of a genetic background that is exclusive for LADA this form of diabetes displays phenotypic characteristics that distinguish it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and lifestyle factors, something that poses problems to therapy and follow-up, perhaps particularly in those with marginal positivity. Yet, there appears to be clear clinical utility in classifying individuals as LADA.

Keywords: Autoimmunity, GADA, C-peptide, islet reactive T-cells, type 1 diabetes, type 2 diabetes.

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DOI https://dx.doi.org/10.2174/1573399814666180716150905	Print ISSN 1573-3998
Publisher Name Bentham Science Publisher	Online ISSN 1875-6417

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