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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Review Article

Effects of Stress on the Mucus-microbial Interactions in the Gut

Author(s): Jianwen He, Huiduo Guo, Weijiang Zheng and Wen Yao*

Volume 20, Issue 2, 2019

Page: [155 - 163] Pages: 9

DOI: 10.2174/1389203719666180514152406

Price: $65

Abstract

Stress shows both direct- and indirect-effects on the functions of the gastrointestinal tract, in particular on the mucus physiology and the composition of microbiota. Mucus mainly consists of heavily glycosylated proteins called mucins, which are secreted by goblet cells. The gut mucus layer is a pivotal part of the intestinal protection and colonized by commensal microbes, essential for the development and health of the host. There is a symbiotic interaction between intestinal microbiota and the host cells. On the one hand, mucus provides nutrients for the growth and adhesion of microbes; on the other hand, mucin-degrading bacteria generate energy sources for the host epithelium. However, the mucusmicrobial interaction has rarely been considered in the context of stress exposure. Therefore, this paper principally reviews the effects of stress on both mucus secretion and gut microbiota and is hoped to provide a new perspective for future study.

Keywords: Stress, mucus, mucin, bacterial component, gut microbiota, mucin-degradation.

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