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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Review Article

How Can Xenosensors Act in Chemical Detoxification Metabolism?

Author(s): Dongsheng Che, Mohammed Hamdy Farouk*, Ibrahim Abd El-Razek, Adams Seidu, Naydia Ekua Ekuful, Guixin Qin, Hailong Jiang and Lianyu Yang*

Volume 20, Issue 2, 2019

Page: [172 - 183] Pages: 12

DOI: 10.2174/1389203719666180514144955

Price: $65

Abstract

There are some disparities between pharmacological and toxicological xenobiotic receptor (xenosensors) pathways. These variations include receptor models that indicate several toxic patterns. Such models have demanded some update from traditional medical receptor relations studied by pharmacologists. These may include the response time, the molecular level, and unclear directions of toxicological metabolism. Xenosensors activities were affected by many factors that include genetic elements, physiological status, xenobiotic complication, and species-specific variations. Thus, this review aims to highlight the most advanced features of xenosensors related to toxicant biotransformations and other patterns such as characteristics, recognition, and the relations between different xenosensors.

Keywords: AhR, nuclear receptors, species variations, toxic metabolism, Xenosensors, detoxification.

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