Abstract
Despite widespread clinical use of anesthetics, the exact mechanisms of anesthetic action are unclear. In terms of physiological action, a broad mechanism of general anesthesia including perturbations of neurotransmission has been suggested. However, the mechanism of anesthetic action at the molecular level is less clear. Specifically, how anesthetics affect neurons and glial cells and which proteins they interact with remains to be explored. Several recent studies have investigated the molecular interactions between proteins and anesthetics. In this review, we summarize the molecular mechanisms of anesthetic action in the intracellular signaling pathways of neuronal and glial cells.
Keywords: Anesthetics, target protein, G-protein coupled receptor, ligand-gated ion channel, CAMkinase, integrin, cytoskeleton, SIRT2 deacetylase.
Current Drug Targets
Title:Anesthetics Mechanisms: A Review of Putative Target Proteins at the Cellular and Molecular Level
Volume: 19 Issue: 11
Author(s): Danuh Kim, Hyun Joo Kim and Seunghyun Ahn*
Affiliation:
- Institute for Drug Discovery, Crystal Genomics, Inc. Gyonggi-do,Korea
Keywords: Anesthetics, target protein, G-protein coupled receptor, ligand-gated ion channel, CAMkinase, integrin, cytoskeleton, SIRT2 deacetylase.
Abstract: Despite widespread clinical use of anesthetics, the exact mechanisms of anesthetic action are unclear. In terms of physiological action, a broad mechanism of general anesthesia including perturbations of neurotransmission has been suggested. However, the mechanism of anesthetic action at the molecular level is less clear. Specifically, how anesthetics affect neurons and glial cells and which proteins they interact with remains to be explored. Several recent studies have investigated the molecular interactions between proteins and anesthetics. In this review, we summarize the molecular mechanisms of anesthetic action in the intracellular signaling pathways of neuronal and glial cells.
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Cite this article as:
Kim Danuh, Kim Joo Hyun and Ahn Seunghyun *, Anesthetics Mechanisms: A Review of Putative Target Proteins at the Cellular and Molecular Level, Current Drug Targets 2018; 19 (11) . https://dx.doi.org/10.2174/1389450119666180502112029
DOI https://dx.doi.org/10.2174/1389450119666180502112029 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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