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Current Nutrition & Food Science

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ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

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Research Article

Cardioprotective Activity of Agaricus bisporus Against Isoproterenol- Induced Myocardial Infarction in Laboratory Animals

Author(s): Apoorva Bhushan and Mayank Kulshreshtha*

Volume 15, Issue 4, 2019

Page: [401 - 407] Pages: 7

DOI: 10.2174/1573401314666180427161119

Price: $65

Abstract

Background: Agaricus bisporus (A. bisporus) is an edible basidiomycete mushroom native to grasslands in Europe and North America. A. bisporus, commonly known as white button mushroom (WBM), is widely cultivated in most countries, and it constitutes the bulk of all mushrooms consumed in the United States and Australia. Traditionally this fungus has used in the treatment of heart diseases. Also it has anti-ageing property.Mushrooms have been found effective against cancer, cholesterol reduction, stress, insomnia, asthma, allergies and diabetes.

Objective: The present research was designed to appraise the cardioprotective activity of a hydroalcoholic extract of Agaricus bisporus (EEAB) on Isoproterenol (ISO) induced myocardial infarction (MI) in Albino Wistar rat. Traditionally, Agaricus bisporus is reported in the treatment of heart diseases, cancer, cerebral stroke and anti-ageing property.

Materials and Methods: Wistar rats of different sex were randomly split into five groups namely positive control, negative control, standard, test-1 and test-2 and received distilled water, ISO (85 mg/kg), Simvastatin (10 mg/kg/day, oral) and EEAB (200 and 400 mg/kg/day, p.o.) for 30 days, respectively. MI was induced in rats by ISO at an interval of 24 hrs on 31 and 32 day and on the next day, blood was amassed through retro-orbital plexus for the assessment of biochemical markers (cholesterol, lowdensity lipoprotein, high-density lipoprotein, very low-density lipoprotein, triglycerides, alanine aminotransferase and total protein) and finally, the rats were immolated by cervical dislocation. The heart tissue was reaped instantly, cleaned with chilled isotonic saline and clasped in 10% buffered formalin and used for the histopathological analysis.

Results: ISO p.o. administration significantly elevated the cholesterol, low density lipoprotein, very low density lipoprotein, triglycerides, alanine aminotransferase and aspartate aminotransferase levels while it decreases high-density lipoprotein and total protein in plasma and administration of EEAB decreases the level of cholesterol, low-density lipoprotein, very low-density lipoprotein, triglycerides, alanine aminotransferase and aspartate aminotransferase levels while it increases high-density lipoprotein and total protein levels. Pretreatment with EEAB protected the cardiotoxicity induced by ISO. The histopathological findings support the analysis of biochemical parameters, ISO-induced myocardium showed infracted zone with edema, inflammatory cells, lipid droplets, myocardial necrosis and vacuolization of myofibrils which were reduced.

Conclusion: It can be an outcome that EEAB possessed cardioprotective activity against experimental and clinical studies of ISO-induced myocardial infarction in rats.

Keywords: Agaricus bisporus, cardioprotective activity, histopathological analysis, isoproterenol, myocardial infarction, simvastatin.

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[1]
Khalili H, Talasaz AH, Jenab Y, Salarifar M. Clinical characteristics and risk assessment of ST-segment elevation myocardial infarction patients of an Iranian referral center. J Cardiovasc Med 2012; 13(11): 708-15.
[2]
Upaganlawar A, Patel V, Balaraman R. Tomato lycopene attenuates myocardial infarction induced by isoproterenol electrocardiographic, biochemical and anti-apopitotic study. Asian Pac J Trop Biomed 2012; 2(5): 345-51.
[3]
Aronow WS. Epidemiology, pathophysiology, prognosis and treatment of systolic and diastolic heart failure. Cardiol Rev 2006; 14(3): 108-24.
[4]
Lee PYM, Cheng Y, Chen SY, Chung MT, Sheu JR. Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats. J Cardiovasc Pharmacol 2011; 58(2): 133-42.
[5]
Carluccio A. The complete mushroom book. Quadrille: London, United Kingdom. 2003.
[6]
Jeong SC, Jeong YT, Yang BK. White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res 2010; 30: 49-56.
[7]
Kerrigan RW. Global genetic resources for Agaricus breeding and cultivation. Can J Bot 1995; 73(S1): 973-9.
[8]
De Barros LB. Chemical characterization and bioactive properties of portuguese wild edible mushrooms PhD Thesis. De Farmacis: De Salamanca-Fac.University. 2008.
[9]
Murugesan M, Revathi R, Manju V. Cardioprotective effect of Fenugreek on Isoproterenol-induced myocardial infarctions in rats. Indian J Pharmacol 2011; 43(5): 516-9.
[10]
Haripyaree A, Guneshwor K, Damayant M. Evaluation of An tioxidant Properties of phenolics Extracted from Ananas comosus L. Not Sci Biol 2010; 2(2): 68-71.
[11]
Evans WC, Evans D, Trease GE. Trease and Evan’s pharmacognosy. 16th ed. Elsevier: Amsterdam, Netherlands. 2009.
[12]
Wang BS, Tian S, Yang GH, Yang YX, Du HG. Cardioprotective effect of salvianolic acid A on Isoproterenol-induced myocardial infarction in rats. Eur J Pharmacol 2009; 615(1-3): 125-32.
[13]
Pitroda KD, Sachdeva PD. Evaluation of cardio protective effect of Averrhoa carambola fruit in isoproterenol induced myocardial infarction in rats. Int J Pharm Sci Res 2016; 7(7): 2845-51.
[14]
Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006; 3: 2011-3.
[15]
Denolle J, Sys SU, Brutsaert DL. Personality and mortality after myocardial infarction. Psychosom Med 1995; 57: 582-91.
[16]
Pandey KB, Rizvi SI. Current understanding of dietary polyphenols and their role in health and disease. Curr Nutr Food Sci 2009; 5: 249-56.
[17]
Ginter E, Simko V. Plant polyphenols in prevention of heart disease. Bratisl Med J 2012; 113: 476-80.
[18]
Kalyoncu IH, Kaşik G, Özcan M, Öztürk C. Effects of sesame and bitter almond seed oils on mycelium growth of Agaricus bisporus (Lange). Sing Grasas y Aceites 1999; 50(5): 392-4.
[19]
Szymczak S. Changes in chemical compositions of the fruit-body of the mushrooms, Agaricus bisporus Lange at the different stages of development. Bromatologia Cehmia Toksykologiczna 1972; 5(1): 5-8.
[20]
Hiroi M, Tsuyuki H. Comparision of fatty acid composition in fruit body and spore of mushrooms. Bulletin of the Collage of Agricultural and Veterinary Medicine. Nihon University 1998; 45: 104-9.
[21]
Manzi P, Aguzzi A, Vivanti V, Pizzoferrato L. Nutritional value of mushrooms widely consumed in Italy. Food Chem 2001; 73: 321-5.
[22]
Dursun N, Özcan M, Kasık G, Öztürk C. Mineral contents of 35 species of edible mushrooms growing wild in Turkey. J Sci Food Agric 2005; 86: 1087-94.
[23]
Bhushan A, Kulshreshtha M. The medicinal mushroom Agaricus bisporus: Review of phytopharmacology and potential role in the treatment of various diseases. J Nat Sci Med 2018; 1: 41-7.
[24]
Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN. Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol 2014; 7(2): 60-72.
[25]
Nagoor MMF, Stanely MPP, Hidhayath BR. Preventive effects of N-acetyl cysteine on lipids: lipoproteins and myocardial infarct size in isoproterenol induced myocardial infarcted rats: An in vivo and in vitro study. Eur J Pharmacol 2012; 677: 116-22.
[26]
Laine GA, Allen SJ. Left ventricular myocardial edema. Lymph flow, interstitial fibrosis, and cardiac function. Circ Res 1991; 68(6): 1713-21.
[27]
Rona G. Catecholamine cardiotoxicity. J Mol Cell Cardiol 1985; 17(4): 291-306.
[28]
Singal PK, Kapur N, Dhillon KS, Beamish RE, Dhalla NS. Role of free radicals in catecholamine-induced cardiomyopathy. Can J Physiol Pharmacol 1982; 60(11): 1390-7.
[29]
Zaafan AM, Zaki FH, El-Brairy IA, Kenawy AS. Protective effects of Atorvastatin and quercetin on Isoprenaline-induced myocardial infarction in rats. Bulletin Faculty Pharm Cairo Univ 2013; 51: 35-41.
[30]
Lalitha G, Poornima P, Archanah A, Padma VV. Protective effect of neferine against isoproterenol-induced cardiac toxicity. Cardiovasc Toxicol 2013; 13(2): 168-79.
[31]
Punithavathi VR, Prince PSM. Combined effects of quercetin and a-tocopherol on lipids and glycoprotein components in isoproterenol induced myocardial infarcted Wistar rats. Chem Biol Interact 2009; 181(3): 322-7.
[32]
Patel DK, Desai SN, Gandhi HP, Devkar RV, Ramachandran AV. Cardio protective effect of Coriandrum sativum L. on isoproterenol induced myocardial necrosis in rats. Food Chem Toxicol 2012; 50: 3120-5.
[33]
Upaganlawar A, Patel V, Balaraman R. Tomato lycopene attenuates myocardial infarction induced by isoproterenol electrocardiographic, biochemical and anti-apopitotic study. Asian Pac J Trop Biomed 2012; 2(5): 345-51.

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