Abstract
Background: Mild (MCI) and Subjective Cognitive Impairment (SCI) are conditions at risk of developing Alzheimer’s disease (AD). Differential between normal aging at early stages can be really challenging; available biomarkers need to be combined and can be quite invasive and expensive.
Objective: The aim of this pilot study is to examine possible EEG alterations in MCI and SCI compared to controls, analyzing if a cognitive task could highlight early AD hallmarks.
Method: We recruited 11 MCI, 8 SCI and 7 healthy subjects as controls (CS), all matched for age and education. Neuropsychological assessment and EEG recording, at resting state and during a mental memory task, were performed. Classical spectral measures and nonlinear parameters were used to characterize EEGs.
Results: During cognitive task, α-band power reduction was found predominantly in frontal regions in SCI and CS, diffused to all regions in MCI; moreover, decreased EEG complexity was found in SCI compared to controls. The α -band power attenuation restricted to frontal regions in SCI during a free recall task (involving frontal areas), suggests that MCI patients compensate for encoding deficit by activating different brain networks to perform the same task. Furthermore, EEG complexity reduction - that has been found already in SCI - could be a possible early hallmark of AD.
Conclusion: This study draws attention on the importance of nonlinear approach in EEG analysis and the potential role of cognitive task in highlighting EEG alterations at very early stages of cognitive impairment; EEG could therefore have a practical impact on dementia diagnosis.
Keywords: Mild cognitive impairment (MCI), subjective cognitive impairment (SCI), early Alzheimer's disease, memorization task, nonlinear EEG analysis, EEG signal complexity.
Current Alzheimer Research
Title:Memorization Test and Resting State EEG Components in Mild and Subjective Cognitive Impairment
Volume: 15 Issue: 9
Author(s): Giulia Mazzon*, Federica De Dea, Tatiana Cattaruzza, Paolo Manganotti, Fabrizio Monti and Agostino Accardo
Affiliation:
- Neurological Clinic, Department of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume 447, 34149, Trieste,Italy
Keywords: Mild cognitive impairment (MCI), subjective cognitive impairment (SCI), early Alzheimer's disease, memorization task, nonlinear EEG analysis, EEG signal complexity.
Abstract: Background: Mild (MCI) and Subjective Cognitive Impairment (SCI) are conditions at risk of developing Alzheimer’s disease (AD). Differential between normal aging at early stages can be really challenging; available biomarkers need to be combined and can be quite invasive and expensive.
Objective: The aim of this pilot study is to examine possible EEG alterations in MCI and SCI compared to controls, analyzing if a cognitive task could highlight early AD hallmarks.
Method: We recruited 11 MCI, 8 SCI and 7 healthy subjects as controls (CS), all matched for age and education. Neuropsychological assessment and EEG recording, at resting state and during a mental memory task, were performed. Classical spectral measures and nonlinear parameters were used to characterize EEGs.
Results: During cognitive task, α-band power reduction was found predominantly in frontal regions in SCI and CS, diffused to all regions in MCI; moreover, decreased EEG complexity was found in SCI compared to controls. The α -band power attenuation restricted to frontal regions in SCI during a free recall task (involving frontal areas), suggests that MCI patients compensate for encoding deficit by activating different brain networks to perform the same task. Furthermore, EEG complexity reduction - that has been found already in SCI - could be a possible early hallmark of AD.
Conclusion: This study draws attention on the importance of nonlinear approach in EEG analysis and the potential role of cognitive task in highlighting EEG alterations at very early stages of cognitive impairment; EEG could therefore have a practical impact on dementia diagnosis.
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Cite this article as:
Mazzon Giulia *, De Dea Federica , Cattaruzza Tatiana , Manganotti Paolo , Monti Fabrizio and Accardo Agostino, Memorization Test and Resting State EEG Components in Mild and Subjective Cognitive Impairment, Current Alzheimer Research 2018; 15 (9) . https://dx.doi.org/10.2174/1567205015666180427114520
DOI https://dx.doi.org/10.2174/1567205015666180427114520 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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