Key Updates on the Chemistry and Biological Roles of Thiazine Scaffold: A Review

Title:Key Updates on the Chemistry and Biological Roles of Thiazine Scaffold: A Review

Volume: 18 Issue: 17

Author(s): Shalki Choudhary, Om Silakari*Pankaj Kumar Singh

Affiliation:

• Molecular Modeling Lab, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, 147002,India

Keywords: Thiazine, antimicrobial, antifungal, antimalarial, anticancer, thiazine scaffold.

Abstract: Nitrogen and sulphur based heterocyclic molecules have gained significant attention owing to their broad spectrum pharmacological profiles. Thiazine is one of such promising scaffolds which has been widely utilized in the synthesis of compounds that possess interesting biological profile including anti-proliferative, anti-bacterial, antipsychotic, analgesic, anti-inflammatory, antifungal and antiviral activities. The current review focuses on the chemistry of thiazine and its derivatives along with potential pharmacological activities reported for these in scientific literature. Multifaceted pharmacological profile of thiazine derivatives provides new aspects for the design of superior medicinally active agents.

Cite this article as:

Choudhary Shalki , Silakari Om*, Singh Kumar Pankaj , Key Updates on the Chemistry and Biological Roles of Thiazine Scaffold: A Review, Mini-Reviews in Medicinal Chemistry 2018; 18 (17) . https://dx.doi.org/10.2174/1389557518666180416150552