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Current Drug Metabolism

Editor-in-Chief

ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Review Article

Real-time Monitoring of Nanoparticle-based Therapeutics: A Review

Author(s): Qingqing Han, Meng Niu, Qirun Wu and Hongshan Zhong*

Volume 19, Issue 2, 2018

Page: [124 - 130] Pages: 7

DOI: 10.2174/1389200219666180212113426

Price: $65

Abstract

Background: With the development of nanomaterials, nanoparticle-based therapeutics have found increasing application in various fields, including clinical and basic medicine. Real-time monitoring of nanoparticle-based therapeutics is considered critical to both pharmacology and pharmacokinetics.

Methods: In this review, we discuss the different methods of real-time monitoring of nanoparticle-based therapeutics comprising different types of nanoparticle carriers, such as metal nanoparticles, inorganic nonmetallic nanoparticles, biodegradable polymer nanoparticles, and biological nanoparticles.

Results: In the light of examples and analyses, we conclude that the methods of analysis of the four types of nanoparticle carriers are commonly used methods and mostly not necessary. Under most circumstances, real-time monitoring differs according to nanoparticle type, drugs, diseases, and surroundings.

Conclusion: With technology development and advanced researches, there have been increasing measures to track the real-time changes in nanoparticles, and this has led to great progress in pharmacology and therapeutics. However, future studies are warranted to determine the accuracy, applicability, and practicability of different technologies.

Keywords: Nanoparticle drugs, metal nanoparticles, nanoliposomes, solid lipid nanoparticles, surface-enhanced Raman scattering, PTT, MRI.

Graphical Abstract

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