Abstract
Myocardial Infarction (MI) with Non-obstructive Coronary Arteries (MINOCA) is a syndrome with underlying many causes. MINOCA incidence is estimated to be between 5% and 25% of all MI. The outcome is extremely variable depending on the MINOCA cause. Clinical history, laboratory tests, echocardiography and coronary angiography are the first line diagnostic investigations. Nevertheless, further tests are frequently necessary (e.g. optical coherence tomography, invasive provocative test with acetylcholine or cardiac magnetic resonance) to establish the exact cause, and allowing the adequate risk stratification and management. This is crucial since many patients, particularly those with angiographically normal coronary arteries, are often labelled as ‘noncardiac', therefore missing the chance for appropriate treatment. And this group of patients characterizes substantially worse outcome than previously it was believed. Here, we have reviewed the pathogenesis, diagnosis, prognosis, and management of MINOCA caused by coronary vasospasm or coronary microcirculation dysfunction.
Keywords: Variant angina, coronary spasm, vasospasm, acetylcholine, myocardial infarction with non-obstructive coronary arteries, coronary angiography.
Current Pharmaceutical Design
Title:Advances in Mechanisms and Treatment Options of MINOCA Caused by Vasospasm or Microcirculation Dysfunction
Volume: 24 Issue: 4
Author(s): Jacek Bil*, Natalia Pietraszek, Tomasz Pawlowski and Robert J. Gil
Affiliation:
- Department of Invasive Cardiology, Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw,Poland
Keywords: Variant angina, coronary spasm, vasospasm, acetylcholine, myocardial infarction with non-obstructive coronary arteries, coronary angiography.
Abstract: Myocardial Infarction (MI) with Non-obstructive Coronary Arteries (MINOCA) is a syndrome with underlying many causes. MINOCA incidence is estimated to be between 5% and 25% of all MI. The outcome is extremely variable depending on the MINOCA cause. Clinical history, laboratory tests, echocardiography and coronary angiography are the first line diagnostic investigations. Nevertheless, further tests are frequently necessary (e.g. optical coherence tomography, invasive provocative test with acetylcholine or cardiac magnetic resonance) to establish the exact cause, and allowing the adequate risk stratification and management. This is crucial since many patients, particularly those with angiographically normal coronary arteries, are often labelled as ‘noncardiac', therefore missing the chance for appropriate treatment. And this group of patients characterizes substantially worse outcome than previously it was believed. Here, we have reviewed the pathogenesis, diagnosis, prognosis, and management of MINOCA caused by coronary vasospasm or coronary microcirculation dysfunction.
Export Options
About this article
Cite this article as:
Bil Jacek*, Pietraszek Natalia , Pawlowski Tomasz and Gil J. Robert , Advances in Mechanisms and Treatment Options of MINOCA Caused by Vasospasm or Microcirculation Dysfunction, Current Pharmaceutical Design 2018; 24 (4) . https://dx.doi.org/10.2174/1381612824666180108121253
DOI https://dx.doi.org/10.2174/1381612824666180108121253 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Chronic Complications of Diabetes Mellitus: A Mini Review
Current Diabetes Reviews Cardiovascular Disease in Juvenile Idiopathic Arthritis
Current Vascular Pharmacology Effect of Flavonoids on Human Health: Old Subjects but New Challenges
Recent Patents on Biotechnology Regional Anesthesia and Analgesia: Their Role in Postoperative Outcome
Current Topics in Medicinal Chemistry Potential Applications of Hydrogen Sulfide-Induced Suspended Animation
Current Medicinal Chemistry TRPV1 Function in Health and Disease
Current Pharmaceutical Biotechnology Fighting Type-2 Diabetes: Present and Future Perspectives
Current Medicinal Chemistry Is There a True Beneficial Effect of Statin Therapy in the Acute Phase of Unstable Angina or Myocardial Infarction?
Current Vascular Pharmacology Generation of Human Cardiomyocytes for Cardiac Regenerative Therapies: Differentiation and Direct Reprogramming
Current Pharmaceutical Design Good at Heart: Preserving Cardiac Metabolism during aging
Current Diabetes Reviews Cardiac Workup of Ischemic Stroke
Current Cardiology Reviews Dynamic Changes in Phenotypic Groups in Patients with Stable Angina Pectoris after Treatment with Xinxuekang Capsule: A Randomized Controlled Trial
Current Vascular Pharmacology The Quest for Novel Biomarkers in Early Diagnosis of Diabetic Neuropathy
Current Proteomics LncRNA as a Therapeutic Target for Angiogenesis
Current Topics in Medicinal Chemistry Tetracyclines: Drugs with Huge Therapeutic Potential
Mini-Reviews in Medicinal Chemistry Intracardiac Origin of Heart Rate Variability, Pacemaker Funny Current and their Possible Association with Critical Illness
Current Cardiology Reviews Research Strategies for Pain in Lumbar Radiculopathy Focusing on Acid-Sensing Ion Channels and Their Toxins
Current Topics in Medicinal Chemistry Local Renin-Angiotensin II Systems, Angiotensin-Converting Enzyme and its Homologue ACE2: Their Potential Role in the Pathogenesis of Chronic Obstructive Pulmonary Diseases, Pulmonary Hypertension and Acute Respiratory Distress Syndrome
Current Medicinal Chemistry Long-term Reproductive and Metabolic Consequences of PCOS
Current Diabetes Reviews Diagnosis and Management of Heart Failure with Preserved Ejection Fraction: 10 Key Lessons
Current Cardiology Reviews