Transition Metal-Catalyzed Carboxylation of Terminal Alkynes with CO2

Title:Transition Metal-Catalyzed Carboxylation of Terminal Alkynes with CO2

Volume: 15 Issue: 4

Author(s): Chang Qiao, Yu Cao and Liang-Nian He*

Affiliation:

• State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Nankai Qu,China

Keywords: Carbon dioxide, carboxylation, terminal alkyne, propiolic acids, transition metal, catalysis.

Abstract: The coupling reaction of terminal alkynes and CO2 provides a promising way to synthesize propiolic acids. Among the existing catalytic systems, transition-metal copper and silver exhibit excellent catalytic efficiency under mild conditions probably being attributed to the activation of C-C triple bond of terminal alkynes. In this aspect, efficient strategies for activating both substrate and CO2 are often smart choices. This review summarizes the development trend of the Cu/Ag-catalyzed carboxylation reactions of terminal alkynes with CO2, and representative examples are also discussed in detail.

Cite this article as:

Qiao Chang , Cao Yu and He Liang-Nian*, Transition Metal-Catalyzed Carboxylation of Terminal Alkynes with CO2, Mini-Reviews in Organic Chemistry 2018; 15 (4) . https://dx.doi.org/10.2174/1570193X15666180101150819