Synthesis and Bioevaluation of Shikonin Derivatives

Title:Synthesis and Bioevaluation of Shikonin Derivatives

Volume: 15 Issue: 9

Author(s): Sufen Cao, Jiangang Zhang and Wenhu Duan*

Affiliation:

• Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, Shanghai,China

Keywords: Amidation, chemical stability, cytotoxicity, esterification, shikonin derivatives, synthesis, SRB assay, cell lines.

Abstract: Background: Ester and amide derivatives of shikonin were synthesized to improve the chemical stability of shikonin.

Methods: All synthesized compounds were evaluated for their antiproliferative activity against A549 cell line by SRB assay, and five of them demonstrated comparable cytotoxicity to shikonin.

Results and Conclusion: The most potent compound, 22d, was more stable and potent than shikonin.

Cite this article as:

Cao Sufen , Zhang Jiangang and Duan Wenhu *, Synthesis and Bioevaluation of Shikonin Derivatives, Letters in Drug Design & Discovery 2018; 15 (9) . https://dx.doi.org/10.2174/1570180815666171229152139