Synergic Strategies for the Enhanced Self-Assembly of Biomineralization Peptides for the Synthesis of Functional Nanomaterials

Title:Synergic Strategies for the Enhanced Self-Assembly of Biomineralization Peptides for the Synthesis of Functional Nanomaterials

Volume: 25 Issue: 1

Author(s): Jose Isagani B. Janairo, Tatsuya Sakaguchi, Kenta Mine, Rui Kamada and Kazuyasu Sakaguchi*

Affiliation:

• Laboratory of Biological Chemistry, Department of Chemistry, Faculty of Science, Hokkaido University, N10 W8, Kita-ku, 060-0810 Sapporo,Japan

Keywords: Amyloid, biomineralization peptide, molecular scaffold, nanowire, nanostructure, oligomerization, self-assembly, tumor suppressor protein.

Abstract: Introduction: Peptide-mediated biomineralization is a promising bioinspired technique of nanostructure formation. The biomineralization peptide is responsible for the regulation of the growth and morphology of the inorganic nanostructure. The 3D properties of the biomineralization peptide is a crucial factor in which the success of creating functional nanomaterials depends on. However, given the relatively short sequence of most biomineralization peptides, controlling the multivalency and spatial orientation of the peptide can be a challenging endeavor.

Objective: This mini-review details recent advances in enhancing the self-assembly and 3D properties of the biomineralization peptide. The design and creation of fusion peptides is highlighted, which involves the conjugation of the biomineralization peptide with a control element. The control element is responsible for directing the self-assembly of the biomineralization peptide.

Conclusion: A variety of control elements that can direct the self-assembly of biomineralization peptides are available. The control element can be a small organic molecule such as a biphenyl, or a peptide segment such as the p53 tetramerization domain or the amyloid peptide. The high diversity of existing control elements further increases the ability of peptide-mediated biomineralization to create functional nanomaterials.

Cite this article as:

Janairo Isagani B. Jose , Sakaguchi Tatsuya , Mine Kenta , Kamada Rui and Sakaguchi Kazuyasu *, Synergic Strategies for the Enhanced Self-Assembly of Biomineralization Peptides for the Synthesis of Functional Nanomaterials, Protein & Peptide Letters 2018; 25 (1) . https://dx.doi.org/10.2174/0929866525666171214110206