Abstract
Background: Natto, a fermented soybean food, has been consumed by oriental people for more than 1000 years. Nattokinase, formerly called subtilisin NAT, is a well-studied protease of microbial origin that possesses fibrinolytic (anti-clotting) activities. Due to its strong fibrinolytic and thrombolytic activity, Nattokinase is regarded as a precious dietary supplement or nutraceutical for the oral thrombolytic therapy. Nattokinase is witnessed to be a useful enzyme for the complete removal of the vitreous and associated proliferative tissues in proliferative vitreo retinal disorders.
Conclusion: This review focuses on the native and recombinant Nattokinase from bacteria and other sources, their production, purification, immobilization and nano-immobilization studies, which aid in ameliorating their properties to suit the targeted industrial applications. Recent development in these fields are presented and discussed, and prospective developments are suggested.
Keywords: Cardiovascular disease, nano immobilization, fibrinolytic enzymes, recombinant Nattokinase, hypertention, myocardial infarction.
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title:Nattokinase: An Updated Critical Review on Challenges and Perspectives
Volume: 15 Issue: 2
Author(s): E. Selvarajan*Niharika Bhatnagar
Affiliation:
- Department of Genetic Engineering, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu,India
Keywords: Cardiovascular disease, nano immobilization, fibrinolytic enzymes, recombinant Nattokinase, hypertention, myocardial infarction.
Abstract: Background: Natto, a fermented soybean food, has been consumed by oriental people for more than 1000 years. Nattokinase, formerly called subtilisin NAT, is a well-studied protease of microbial origin that possesses fibrinolytic (anti-clotting) activities. Due to its strong fibrinolytic and thrombolytic activity, Nattokinase is regarded as a precious dietary supplement or nutraceutical for the oral thrombolytic therapy. Nattokinase is witnessed to be a useful enzyme for the complete removal of the vitreous and associated proliferative tissues in proliferative vitreo retinal disorders.
Conclusion: This review focuses on the native and recombinant Nattokinase from bacteria and other sources, their production, purification, immobilization and nano-immobilization studies, which aid in ameliorating their properties to suit the targeted industrial applications. Recent development in these fields are presented and discussed, and prospective developments are suggested.
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Cite this article as:
Selvarajan E.*, Bhatnagar Niharika, Nattokinase: An Updated Critical Review on Challenges and Perspectives, Cardiovascular & Hematological Agents in Medicinal Chemistry 2017; 15 (2) . https://dx.doi.org/10.2174/1871525716666171207153332
DOI https://dx.doi.org/10.2174/1871525716666171207153332 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
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