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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Natural Bioactive New Withanolides

Author(s): Qian-Qian Xu and Kui-Wu Wang*

Volume 20, Issue 12, 2020

Page: [1101 - 1117] Pages: 17

DOI: 10.2174/1389557518666171129164056

Price: $65

Abstract

Withanolides are a group of highly oxygenated steroids derived from a C28 ergostane skeleton, and have attracted significant scientific interest due to their complex structural features and multiple bioactivities. More than 170 new natural withanolides were isolated and identified in the last 5 years. This review provides a comprehensive summary of the structural, biological and pharmacological activities of these new compounds.

Keywords: Withanolide, structure, biological activities, anti-inflammatory, oxygenated steroids, antistress.

Graphical Abstract
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