Abstract
Numerous authors have provided evidence regarding the beneficial effects of phenolic acids and their derivatives against Alzheimer's disease (AD). In this review, the role of phenolic acids as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the structure-activity relationship. In addition, the inhibitory effect of phenolic acids on the formation of amyloid β-peptide (Aβ) fibrils is presented. We also cover the in vitro, ex vivo, and in vivo studies concerning the prevention and treatment of the cognitive enhancement.
Keywords: Alzheimer's disease, amyloid β-peptide, cinnamic acid, benzoic acid, acetylcholinesterase, butyrylcholinesterase, cognition.
Current Alzheimer Research
Title:Phenolic Acids Exert Anticholinesterase and Cognition-Improving Effects
Volume: 15 Issue: 6
Author(s): Dominik Szwajgier*, Ewa Baranowska-Wojcik and Kamila Borowiec
Affiliation:
- Department of Biotechnology, University of Life Sciences in Lublin, Human Nutrition and the Science of Food Commodities, Skromna Street 8, Lublin 20-950,Poland
Keywords: Alzheimer's disease, amyloid β-peptide, cinnamic acid, benzoic acid, acetylcholinesterase, butyrylcholinesterase, cognition.
Abstract: Numerous authors have provided evidence regarding the beneficial effects of phenolic acids and their derivatives against Alzheimer's disease (AD). In this review, the role of phenolic acids as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the structure-activity relationship. In addition, the inhibitory effect of phenolic acids on the formation of amyloid β-peptide (Aβ) fibrils is presented. We also cover the in vitro, ex vivo, and in vivo studies concerning the prevention and treatment of the cognitive enhancement.
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Cite this article as:
Szwajgier Dominik *, Baranowska-Wojcik Ewa and Borowiec Kamila , Phenolic Acids Exert Anticholinesterase and Cognition-Improving Effects, Current Alzheimer Research 2018; 15 (6) . https://dx.doi.org/10.2174/1567205014666171128102557
DOI https://dx.doi.org/10.2174/1567205014666171128102557 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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