Abstract
Hepatocellular carcinoma (HCC) is the third most common cause of cancer death worldwide accounting for more than 700 thousand deaths per year. Most of the HCC develops in a cirrhotic liver, a microenvironment where fibrotic tissue replaces parenchymal cells. Thus, there is a close connection between fibrosis and HCC development. Understanding the cellular and molecular mechanisms involved in this process is a crucial step to advance in novel therapeutic or pharmacological strategies to prevent or improve the course of this malignancy. A key molecular player capable of modulating cell growth and fibrosis is the Transforming Growth Factor-beta (TGF-β). Interestingly, TGF-β seems to act like a switch, since it has dual and opposite roles during early and late phases of cancer development. Therefore to develop therapies that target TGF-β signaling pathway for HCC treatment is important to understand the underlying pathogenetic mechanisms at play with special emphasis in the crosstalk between TGF-β and other signaling pathways. In recent years, a plethora of TGR-β have been developed and some of them are under clinical investigations for testing in patients with advanced HCC. In this review, we summarize recent knowledge about the role of TGF-β signaling pathway in HCC progression.
Keywords: TGF-β, hepatocellular carcinoma, HCC, liver cancer, cirrhosis, pathogenesis.
Current Protein & Peptide Science
Title:TGF-β and Hepatocellular Carcinoma: When A Friend Becomes An Enemy
Volume: 19 Issue: 12
Author(s): Marco Arrese, Alejandra Hernandez, Luis Astete, Lisbell Estrada, Claudio Cabello-Verrugio and Daniel Cabrera*
Affiliation:
- Departamento de Gastroenterologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago,Chile
Keywords: TGF-β, hepatocellular carcinoma, HCC, liver cancer, cirrhosis, pathogenesis.
Abstract: Hepatocellular carcinoma (HCC) is the third most common cause of cancer death worldwide accounting for more than 700 thousand deaths per year. Most of the HCC develops in a cirrhotic liver, a microenvironment where fibrotic tissue replaces parenchymal cells. Thus, there is a close connection between fibrosis and HCC development. Understanding the cellular and molecular mechanisms involved in this process is a crucial step to advance in novel therapeutic or pharmacological strategies to prevent or improve the course of this malignancy. A key molecular player capable of modulating cell growth and fibrosis is the Transforming Growth Factor-beta (TGF-β). Interestingly, TGF-β seems to act like a switch, since it has dual and opposite roles during early and late phases of cancer development. Therefore to develop therapies that target TGF-β signaling pathway for HCC treatment is important to understand the underlying pathogenetic mechanisms at play with special emphasis in the crosstalk between TGF-β and other signaling pathways. In recent years, a plethora of TGR-β have been developed and some of them are under clinical investigations for testing in patients with advanced HCC. In this review, we summarize recent knowledge about the role of TGF-β signaling pathway in HCC progression.
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Cite this article as:
Arrese Marco , Hernandez Alejandra , Astete Luis , Estrada Lisbell, Cabello-Verrugio Claudio and Cabrera Daniel*, TGF-β and Hepatocellular Carcinoma: When A Friend Becomes An Enemy, Current Protein & Peptide Science 2018; 19 (12) . https://dx.doi.org/10.2174/1389203718666171117112619
DOI https://dx.doi.org/10.2174/1389203718666171117112619 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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