Abstract
Intranasal drug delivery system provides distinct advantage over conventional drug delivery system for a drug that is pharmacokenetically or biologically unstable. Major concern for the treatment of central nervous system diseases is, low concentration of therapeutically active molecule within brain as blood brain barrier is creating obstacle, where intranasal drug delivery provides direct transport of therapeutically active moiety into brain via olfactory or trigeminal pathway. Nasal mucosa provides distinct advantages like improved bioavailability, law dose and quick onset of action and high patient compliance, and the major disadvantage is residence time of drug and irreversible entrapment of drug. This article provides anatomical and physiological information about nasal route and various factors. Article discusses various types of nanoparticles used intranasally and moreover article also emphasizes patents, formulation under development and some.
Keywords: Brain uptake, drug delivery system, intranasal delivery, nanomedicine, nasal route, pharmacokinetic.
Current Drug Delivery
Title:Nanomedicine for Intranasal Delivery to Improve Brain Uptake
Volume: 15 Issue: 4
Author(s): Amit A. Patel*, Ravish J. Patel*Shachi R. Patel
Affiliation:
- Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus Changa, Anand - 388 421, Gujarat,India
- Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus Changa, Anand - 388 421, Gujarat,India
Keywords: Brain uptake, drug delivery system, intranasal delivery, nanomedicine, nasal route, pharmacokinetic.
Abstract: Intranasal drug delivery system provides distinct advantage over conventional drug delivery system for a drug that is pharmacokenetically or biologically unstable. Major concern for the treatment of central nervous system diseases is, low concentration of therapeutically active molecule within brain as blood brain barrier is creating obstacle, where intranasal drug delivery provides direct transport of therapeutically active moiety into brain via olfactory or trigeminal pathway. Nasal mucosa provides distinct advantages like improved bioavailability, law dose and quick onset of action and high patient compliance, and the major disadvantage is residence time of drug and irreversible entrapment of drug. This article provides anatomical and physiological information about nasal route and various factors. Article discusses various types of nanoparticles used intranasally and moreover article also emphasizes patents, formulation under development and some.
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Cite this article as:
Patel A. Amit*, Patel J. Ravish*, Patel R. Shachi , Nanomedicine for Intranasal Delivery to Improve Brain Uptake, Current Drug Delivery 2018; 15 (4) . https://dx.doi.org/10.2174/1567201814666171013150534
DOI https://dx.doi.org/10.2174/1567201814666171013150534 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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