Abstract
Background: Under the transcriptional control of numerous factors and intracellular signals, mesenchymal stem cells (MSCs) can differentiate into various cell types, including adipocytes and osteoblasts. However, the precise cellular signaling factors that determine the cell fate of MSCs in bone marrow remain largely unknown.
Objective: In this review, we focus on the ties of PPAR-γ and Wnt signaling in MSC differentiation into adipocytes and osteoblasts.
Results: Peroxisome proliferator-activated receptor-γ (PPAR-γ) is well established as a prime inducer of adipogenesis, while the Wnt pathway is regarded as the master moderator of osteogenesis. A theoretical inverse relationship exists between adipogenic and osteogenic lineage commitment and differentiation: the differentiation toward an osteoblast phenotype occurs at the expense of an adipocyte phenotype.
Conclusion: It has been proposed that the balance between osteogenic and adipogeneic MSC differentiation is disrupted in diverse areas of human health. Therefore, understanding the ties between PPAR- γand Wnt signaling in MSC differentiation has significant implications in diverse areas of human health, from obesity to osteoporosis to regenerative medicine.
Keywords: PPAR-γ, Wnt, adipocyte, osteoblast, MSCs, differentiation.
Current Stem Cell Research & Therapy
Title:PPAR-γ and Wnt Regulate the Differentiation of MSCs into Adipocytes and Osteoblasts Respectively
Volume: 13 Issue: 3
Author(s): Yue Li, Daxiang Jin*, Weixing Xie, Longfei Wen, Weijian Chen, Jixi Xu, Jinyong Ding and Dongcheng Ren
Affiliation:
- The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou,China
Keywords: PPAR-γ, Wnt, adipocyte, osteoblast, MSCs, differentiation.
Abstract: Background: Under the transcriptional control of numerous factors and intracellular signals, mesenchymal stem cells (MSCs) can differentiate into various cell types, including adipocytes and osteoblasts. However, the precise cellular signaling factors that determine the cell fate of MSCs in bone marrow remain largely unknown.
Objective: In this review, we focus on the ties of PPAR-γ and Wnt signaling in MSC differentiation into adipocytes and osteoblasts.
Results: Peroxisome proliferator-activated receptor-γ (PPAR-γ) is well established as a prime inducer of adipogenesis, while the Wnt pathway is regarded as the master moderator of osteogenesis. A theoretical inverse relationship exists between adipogenic and osteogenic lineage commitment and differentiation: the differentiation toward an osteoblast phenotype occurs at the expense of an adipocyte phenotype.
Conclusion: It has been proposed that the balance between osteogenic and adipogeneic MSC differentiation is disrupted in diverse areas of human health. Therefore, understanding the ties between PPAR- γand Wnt signaling in MSC differentiation has significant implications in diverse areas of human health, from obesity to osteoporosis to regenerative medicine.
Export Options
About this article
Cite this article as:
Li Yue , Jin Daxiang *, Xie Weixing , Wen Longfei , Chen Weijian , Xu Jixi , Ding Jinyong and Ren Dongcheng , PPAR-γ and Wnt Regulate the Differentiation of MSCs into Adipocytes and Osteoblasts Respectively, Current Stem Cell Research & Therapy 2018; 13 (3) . https://dx.doi.org/10.2174/1574888X12666171012141908
DOI https://dx.doi.org/10.2174/1574888X12666171012141908 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Gut Inflammation: Current Update on Pathophysiology, Molecular Mechanism and Pharmacological Treatment Modalities
Current Pharmaceutical Design Nitric Oxide and Major Depressive Disorder: Pathophysiology and Treatment Implications
Current Molecular Medicine Recent Advances in Epilepsy
Current Neuropharmacology Vaccination to Alzheimer Disease. Is it a Promising Tool or a Blind Way?
Current Medicinal Chemistry A Path to Development or Demise ?
Current Neurovascular Research Adam and Eve - The Story of Two Adolescents
Adolescent Psychiatry Pharmacokinetic and Toxicological Characteristics of Tripterigium Glycosides and Their Derivatives
Current Drug Metabolism Natural Antioxidants in Wheat Sprout Extracts
Current Organic Chemistry Development of Neurochemical Normalization (“Agonist Substitution”) Therapeutics for Stimulant Abuse: Focus on the Dopamine Uptake Inhibitor, GBR12909
Current Medicinal Chemistry - Central Nervous System Agents Detection of Mild Cognitive Impairment Based on Virtual Reality: A Scoping Review
Current Alzheimer Research Protein Kinase A (PKA) - A Potential Target for Therapeutic Intervention of Dysfunctional Immune Cells
Current Drug Targets Healthcare Utilization, Unmet Service Needs, and Medication Adherence Among People Living with HIV/AIDS
Current HIV Research Editorial (Thematic Issue: Cocaine and Amphetamine-Type Stimulants: the Search for Pharmacological Therapies)
Current Pharmaceutical Design Non-Pharmacologic Treatment Options in Rheumatologic Disease
Current Rheumatology Reviews The Patents on Glucocorticosteroids and Selected New Therapies for the Management of Asthma in Children: Update
Recent Patents on Inflammation & Allergy Drug Discovery Neural Correlates in Patients with Major Affective Disorders: An fMRI Study
CNS & Neurological Disorders - Drug Targets Anti-Inflammatory Role of Thyroid Hormones on Rat Air Pouch Model of Inflammation
Inflammation & Allergy - Drug Targets (Discontinued) Melatonin Prevents Hyperhomocysteinemia and Neural Lipid Peroxidation Induced by Methionine Intake
Current Neurovascular Research Role of Opioidergic System in Regulating Depression Pathophysiology
Current Pharmaceutical Design Editorial (Thematic issue: “Alkaloids in Nature: Synthesis, Isolation and Pharmacological Applications” Part 1)
Current Topics in Medicinal Chemistry