Abstract
Background: Quinoxaline is an important nucleus used in the development of novel potentially bioactive structures. Hence, the development of new methodologies that provide access to this scaffold in shorter times and increased yields is of interest. In this work, we review many interesting microwave-assisted methodologies for the synthesis of quinoxalines reported from 2007 to 2015.
Methods: The most prominent methods for the synthesis of quinoxalines under microwave irradiation published in articles from 2007-2015 are reviewed.
Conclusion: Microwave irradiation proved to be a useful tool, providing many advantages on the synthesis of this class, such as shorter reaction times, higher yields and better selectivity, when compared to classical procedures.
Keywords: Catalysis, drugs, green chemistry, microwave, quinoxaline, synthesis.
Current Microwave Chemistry
Title:Microwave-Assisted Synthesis of Quinoxalines - A Review
Volume: 4 Issue: 4
Author(s): Cristiane Franca da Costa, Marcus Vinicius Nora de Souza*, Claudia Regina Brandao Gomes and Victor Facchinetti
Affiliation:
- Departamento de Sintese de Farmacos, Farmanguinhos, Fundacao Oswaldo Cruz, Rio de Janeiro,Brazil
Keywords: Catalysis, drugs, green chemistry, microwave, quinoxaline, synthesis.
Abstract: Background: Quinoxaline is an important nucleus used in the development of novel potentially bioactive structures. Hence, the development of new methodologies that provide access to this scaffold in shorter times and increased yields is of interest. In this work, we review many interesting microwave-assisted methodologies for the synthesis of quinoxalines reported from 2007 to 2015.
Methods: The most prominent methods for the synthesis of quinoxalines under microwave irradiation published in articles from 2007-2015 are reviewed.
Conclusion: Microwave irradiation proved to be a useful tool, providing many advantages on the synthesis of this class, such as shorter reaction times, higher yields and better selectivity, when compared to classical procedures.
Export Options
About this article
Cite this article as:
da Costa Franca Cristiane , Nora de Souza Vinicius Marcus *, Brandao Gomes Regina Claudia and Facchinetti Victor , Microwave-Assisted Synthesis of Quinoxalines - A Review, Current Microwave Chemistry 2017; 4 (4) . https://dx.doi.org/10.2174/2213335604666171010153416
DOI https://dx.doi.org/10.2174/2213335604666171010153416 |
Print ISSN 2213-3356 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3364 |
Call for Papers in Thematic Issues
Microwave Technology: Advancements and Applications in Chemistry, Environment and Food Science
Microwave technology has emerged as a transformative tool in various fields, offering unique opportunities for rapid, efficient, and clean processes. This thematic issue aims to encapsulate the latest research, innovative strategies, and progressive methodologies concerning the application of microwave technology in three main areas: Chemistry: Highlighting the advancements in microwave-assisted ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Atypical GTPases as Drug Targets
Anti-Cancer Agents in Medicinal Chemistry Stem Cell Pharmacogenomics
Current Topics in Medicinal Chemistry CD248: Reviewing its Role in Health and Disease
Current Drug Targets Solenostemma argel: A Rich Source of Very Unusual Pregnane and 14,15- Secopregnane Glycosides with Antiproliferative Activity
Current Organic Chemistry Drug-Induced Nephrotoxicity: Pathogenic Mechanisms, Biomarkers and Prevention Strategies
Current Drug Metabolism Selective VEGFR Inhibitors for Anticancer Therapeutics in Clinical Use and Clinical Trials
Current Pharmaceutical Design Medical Treatment of Gastrointestinal Stromal Tumors: State of the Art and Future Perspectives
Reviews on Recent Clinical Trials Vitamin D, Sunlight, and the Epidemiology of Prostate Cancer
Anti-Cancer Agents in Medicinal Chemistry HIV-Infected Patients and Liver Transplantation: Who, When and Why
Current HIV Research The Use of Therapeutic Peptides to Target and to Kill Cancer Cells
Current Medicinal Chemistry Advancement Towards Tin-based Anticancer Chemotherapeutics: Structural Modification and Computer Modeling Approach to Drug-Enzyme Interactions
Current Topics in Medicinal Chemistry Cutaneous Delivery of Natural Antioxidants: The Enhancement Approaches
Current Pharmaceutical Design Cancer Stem Cells: A New Paradigm for Understanding Tumor Growth and Progression and Drug Resistance
Current Medicinal Chemistry Application of Charge Transfer Reactions for the Quantitative Spectrophotometric Determination of Cyclophosphamide in Pure and Pharmaceutical Formulation
Current Pharmaceutical Analysis Status of Non-Classical Mononuclear Platinum Anticancer Drug Development
Mini-Reviews in Medicinal Chemistry Recent Patents on Nucleic Acid-Based Antiviral Therapeutics
Recent Patents on Anti-Infective Drug Discovery Dihidro-β-Agarofuran Sesquiterpenes: A New Class of Reversal Agents of the Multidrug Resistance Phenotype Mediated by P-Glycoprotein in the Protozoan Parasite Leishmania
Current Pharmaceutical Design Detection of Predictive Markers for Therapeutic Stratification of Salivary Glands Tumors
Current Drug Targets Genetic and Epigenetic Drug Targets in Myelodysplastic Syndromes
Current Pharmaceutical Design Asymmetric Syntheses Based on Organocatalysis
Mini-Reviews in Organic Chemistry