Abstract
Background: Nickel (Ni) is a metal largely present in the environment and prolonged exposure to it may lead to multiple pathological conditions in human subjects. Among these, the most frequent is allergic contact dermatitis.
Methods: Peripheral blood mononuclear cells isolated from 25 patients with Ni-dependent contact dermatitis were evaluated in terms of cytokine release and nitric oxide (NO) production in the presence or absence of two doses (3 and 5 µg, respectively) of polyphenols. Results: Polyphenols were able to reduce the increased release of interferon-γ and interleukin (IL)-4, while maintaining the equilibrium between IL-10 and IL-17. At the same time, exaggerated release of NO was reduced by polyphenol supplementation. Conclusion: In view of their anti-inflammatory activities, polyphenols may represent a potential therapeutic tool to treat Ni-sensitized patients.Keywords: Allergic contact dermatitis, interleukin, nickel, nitric oxide, peripheral blood mononuclear cells, polyphenols.
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:In vitro Effects of Polyphenols on the Peripheral Immune Responses in Nickel-sensitized Patients
Volume: 17 Issue: 4
Author(s): Thea Magrone*, Paolo Romita, Pietro Verni, Rosaria Salvatore, Anna Spagnoletta, Manrico Magrone, Matteo A. Russo, Emilio Jirillo and Caterina Foti
Affiliation:
- Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Bari,Italy
Keywords: Allergic contact dermatitis, interleukin, nickel, nitric oxide, peripheral blood mononuclear cells, polyphenols.
Abstract: Background: Nickel (Ni) is a metal largely present in the environment and prolonged exposure to it may lead to multiple pathological conditions in human subjects. Among these, the most frequent is allergic contact dermatitis.
Methods: Peripheral blood mononuclear cells isolated from 25 patients with Ni-dependent contact dermatitis were evaluated in terms of cytokine release and nitric oxide (NO) production in the presence or absence of two doses (3 and 5 µg, respectively) of polyphenols. Results: Polyphenols were able to reduce the increased release of interferon-γ and interleukin (IL)-4, while maintaining the equilibrium between IL-10 and IL-17. At the same time, exaggerated release of NO was reduced by polyphenol supplementation. Conclusion: In view of their anti-inflammatory activities, polyphenols may represent a potential therapeutic tool to treat Ni-sensitized patients.Export Options
About this article
Cite this article as:
Magrone Thea*, Romita Paolo, Verni Pietro, Salvatore Rosaria, Spagnoletta Anna, Magrone Manrico, Russo A. Matteo, Jirillo Emilio and Foti Caterina, In vitro Effects of Polyphenols on the Peripheral Immune Responses in Nickel-sensitized Patients, Endocrine, Metabolic & Immune Disorders - Drug Targets 2017; 17 (4) . https://dx.doi.org/10.2174/1871530317666171003161314
DOI https://dx.doi.org/10.2174/1871530317666171003161314 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
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