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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Aptamer Oligonucleotides as Potential Therapeutics in Hematologic Diseases

Author(s): Weibin Li, Meng Zhao, Huihui Yan, Kaiyu Wang and XIaopeng lan*

Volume 19, Issue 10, 2019

Page: [788 - 795] Pages: 8

DOI: 10.2174/1389557517666171002160526

Price: $65

Abstract

Aptamers are single-stranded DNA or RNA oligonucleotides generated by a novel in vitro selection technique termed Systematic evolution of ligands by exponential enrichment (SELEX). During the past two decades, various aptamer drugs have been developed and many of them have entered into clinical trials.

In the present review, we focus on aptamers as potential therapeutics for hematological diseases, including anemia of chronic inflammation (ACI) and anemia of chronic disease (ACD), hemophilia, thrombotic thrombocytopenic purpura (TTP) or VWD type-2B, and sickle cell disease (SCD), in particular, those that have entered into clinical trials.

Keywords: Aptamer, anemia, hemophilia, thrombotic thrombocytopenic purpura, VWD type-2B, sickle cell disease.

Graphical Abstract
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