New Therapeutic Targets and Drugs for the Treatment of Asthma

Title:New Therapeutic Targets and Drugs for the Treatment of Asthma

Volume: 18 Issue: 8

Author(s): Mateus Feitosa Alves*, Diogo Vilar da Fonseca, Silvia Adelaide Linhares de Melo, Marcus Tullius Scotti, Luciana Scotti, Socrates Golzio dos Santos and Margareth de Fatima Formiga Melo Diniz

Affiliation:

• Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraiba, Joao Pessoa - PB,Brazil

Keywords: Asthma, drugs, monoclonal antibody, natural products, targets, therapeutic targets.

Abstract: Asthma is an inflammatory disease which affects millions of people worldwide. Therefore, it is necessary to search for new sources of therapies for the treatment of these patients in order to improve their quality of life. From content analysis of literature of new therapeutic targets, there are various targets and drugs reported to be promising for the treatment of asthma. Interleukins involved in inflammatory processes are often presented as candidate targets for new drugs. The action of such therapeutics would not only affect interleukins, but also their receptors. Small molecules (e.g. ligustrazine and SP600125) and large molecule antibodies (e.g. lebrikizumab, benralizumab, dupilumab) are being considered as novel agents for the pharmacotherapy of asthma. Therefore, through this research, we can see advances in the search for new targets and promising drugs to treat asthma. It is expected that these new drug candidates will eventually be approved and marketed so that asthma patients can use them to enhance their quality of life.

Cite this article as:

Alves Feitosa Mateus *, da Fonseca Vilar Diogo , de Melo Adelaide Linhares Silvia , Scotti Tullius Marcus , Scotti Luciana , dos Santos Golzio Socrates and de Fatima Formiga Melo Diniz Margareth, New Therapeutic Targets and Drugs for the Treatment of Asthma, Mini-Reviews in Medicinal Chemistry 2018; 18 (8) . https://dx.doi.org/10.2174/1389557517666170927145011