Abstract
Cognitive function and testosterone level of men decline concurrently with age. Low testosterone levels are associated with higher risk of Alzheimer’s disease and mild cognitive impairment in men. There are continuous debates on whether this relationship is casual. This paper aims to summarize the current evidence on the association between testosterone level and cognitive function in elderly men. The presence of testosterone, androgen receptor and its responsive genes indicates that testosterone has biological functions in the central nervous system. The ability of the body to convert testosterone into estrogen suggests that part of the actions of testosterone could be mediated by estrogen. Observational studies generally showed that low endogenous testosterone levels were associated with poor cognitive performance in healthy elderly men. Testosterone substitution exerted positive effects on certain cognitive domains in normal and hypogonadal elderly men. In conclusion, testosterone may influence cognitive function in elderly men and its substitution may be considered in men with cognitive impairment and testosterone deficiency.
Keywords: Aging, Alzheimer, testosterone, brain, hypogonadism, cognitive ability.
Current Drug Targets
Title:A Review on the Effects of Testosterone Supplementation in Hypogonadal Men with Cognitive Impairment
Volume: 19 Issue: 8
Author(s): Nur Vaizura Mohamad, Soelaiman Ima-Nirwana and Kok-Yong Chin*
Affiliation:
- Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur,Malaysia
Keywords: Aging, Alzheimer, testosterone, brain, hypogonadism, cognitive ability.
Abstract: Cognitive function and testosterone level of men decline concurrently with age. Low testosterone levels are associated with higher risk of Alzheimer’s disease and mild cognitive impairment in men. There are continuous debates on whether this relationship is casual. This paper aims to summarize the current evidence on the association between testosterone level and cognitive function in elderly men. The presence of testosterone, androgen receptor and its responsive genes indicates that testosterone has biological functions in the central nervous system. The ability of the body to convert testosterone into estrogen suggests that part of the actions of testosterone could be mediated by estrogen. Observational studies generally showed that low endogenous testosterone levels were associated with poor cognitive performance in healthy elderly men. Testosterone substitution exerted positive effects on certain cognitive domains in normal and hypogonadal elderly men. In conclusion, testosterone may influence cognitive function in elderly men and its substitution may be considered in men with cognitive impairment and testosterone deficiency.
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Cite this article as:
Mohamad Vaizura Nur, Ima-Nirwana Soelaiman and Chin Kok-Yong *, A Review on the Effects of Testosterone Supplementation in Hypogonadal Men with Cognitive Impairment, Current Drug Targets 2018; 19 (8) . https://dx.doi.org/10.2174/1389450118666170913162739
DOI https://dx.doi.org/10.2174/1389450118666170913162739 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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