Abstract
Leprosy is an infectious disease caused by non-cultivable bacteria Mycobacterium leprae. Ridley and Jopling classified the disease into five polar forms, Tuberculoid (TT) and Lepromatous (LL), in between two forms of the disease Borderline tuberculoid (BT), Borderline (BB) and Borderline lepromatous (BL) are laid. The tuberculoid type (BT/TT) leprosy patients show good recall of cellmediated immune (CMI) response and Th1 type of immune response, while lepromatous leprosy (LL) patients show defect in cell-mediated immunity to the causative agent and Th2 type of immune response. Due to distinct clinical and immunological spectra of the disease, leprosy attracted immunologists to consider an ideal model for the study of deregulations of various immune reactions. Recent studies show that Tregs, Th3 (TGF-β, IL-10), IL-35 producing Treg immune response associated with the immune suppressive environment, survival of bugs. IL-17 producing Th17 immune response associated with tuberculoid leprosy and play protective role. γδ T cells also increased from tuberculoid to lepromatous pole of leprosy. In this review, we will discuss the role of various subtypes of T-cell and their cytokines in the pathogenesis of leprosy.
Keywords: Leprosy, Th1 and Th2 cells, Treg cells, pathogenesis of leprosy, tuberculoid leprosy, cytokines.
Current Protein & Peptide Science
Title:Fate of T Cells and their Secretory Proteins During the Progression of Leprosy
Volume: 19 Issue: 9
Author(s): Mohd Tarique, Chaman Saini, Huma Naz, Raza Ali Naqvi, Faez Iqbal Khan*Alpana Sharma*
Affiliation:
- Department of Chemistry, Rhodes University, Grahamstown 6139,south africa
- Department of Biochemistry, All India Institute of Medical Sciences, AIIMS, New Delhi-110029,India
Keywords: Leprosy, Th1 and Th2 cells, Treg cells, pathogenesis of leprosy, tuberculoid leprosy, cytokines.
Abstract: Leprosy is an infectious disease caused by non-cultivable bacteria Mycobacterium leprae. Ridley and Jopling classified the disease into five polar forms, Tuberculoid (TT) and Lepromatous (LL), in between two forms of the disease Borderline tuberculoid (BT), Borderline (BB) and Borderline lepromatous (BL) are laid. The tuberculoid type (BT/TT) leprosy patients show good recall of cellmediated immune (CMI) response and Th1 type of immune response, while lepromatous leprosy (LL) patients show defect in cell-mediated immunity to the causative agent and Th2 type of immune response. Due to distinct clinical and immunological spectra of the disease, leprosy attracted immunologists to consider an ideal model for the study of deregulations of various immune reactions. Recent studies show that Tregs, Th3 (TGF-β, IL-10), IL-35 producing Treg immune response associated with the immune suppressive environment, survival of bugs. IL-17 producing Th17 immune response associated with tuberculoid leprosy and play protective role. γδ T cells also increased from tuberculoid to lepromatous pole of leprosy. In this review, we will discuss the role of various subtypes of T-cell and their cytokines in the pathogenesis of leprosy.
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Cite this article as:
Tarique Mohd , Saini Chaman , Naz Huma , Naqvi Ali Raza , Khan Iqbal Faez*, Sharma Alpana *, Fate of T Cells and their Secretory Proteins During the Progression of Leprosy, Current Protein & Peptide Science 2018; 19 (9) . https://dx.doi.org/10.2174/1389203718666170829120729
DOI https://dx.doi.org/10.2174/1389203718666170829120729 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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