Abstract
Accumulating evidence has shown the importance of glial cells in the neurobiology of bipolar disorder. Activated microglia and inflammatory cytokines have been pointed out as potential biomarkers of bipolar disorder. Indeed, recent studies have shown that bipolar disorder involves microglial activation in the hippocampus and alterations in peripheral cytokines, suggesting a potential link between neuroinflammation and peripheral toxicity. These abnormalities may also be the biological underpinnings of outcomes related to neuroprogression, such as cognitive impairment and brain changes. Additionally, astrocytes may have a role in the progression of bipolar disorder, as these cells amplify inflammatory response and maintain glutamate homeostasis, preventing excitotoxicity. The present review aims to discuss neuron-glia interactions and their role in the pathophysiology and treatment of bipolar disorder.
Keywords: Bipolar disorder, mania, neuron, glia, microglia, astrocyte, oligodendrocyte, brain-blood barrier.
Current Neuropharmacology
Title:Neuron-glia Interaction as a Possible Pathophysiological Mechanism of Bipolar Disorder
Volume: 16 Issue: 5
Author(s): Jairo Vinicius Pinto, Ives Cavalcante Passos, Diego Librenza-Garcia, Grasiela Marcon, Maiko Abel Schneider, Joao Henrique Conte, Joao Pedro Abreu da Silva, Luiza Pereira Lima, Andre Quincozes-Santos, Marcia Kauer-Sant`Anna and Flavio Kapczinski*
Affiliation:
- Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON,Canada
Keywords: Bipolar disorder, mania, neuron, glia, microglia, astrocyte, oligodendrocyte, brain-blood barrier.
Abstract: Accumulating evidence has shown the importance of glial cells in the neurobiology of bipolar disorder. Activated microglia and inflammatory cytokines have been pointed out as potential biomarkers of bipolar disorder. Indeed, recent studies have shown that bipolar disorder involves microglial activation in the hippocampus and alterations in peripheral cytokines, suggesting a potential link between neuroinflammation and peripheral toxicity. These abnormalities may also be the biological underpinnings of outcomes related to neuroprogression, such as cognitive impairment and brain changes. Additionally, astrocytes may have a role in the progression of bipolar disorder, as these cells amplify inflammatory response and maintain glutamate homeostasis, preventing excitotoxicity. The present review aims to discuss neuron-glia interactions and their role in the pathophysiology and treatment of bipolar disorder.
Export Options
About this article
Cite this article as:
Pinto Vinicius Jairo , Passos Cavalcante Ives, Librenza-Garcia Diego , Marcon Grasiela , Schneider Abel Maiko , Conte Henrique Joao , da Silva Pedro Abreu Joao , Lima Pereira Luiza , Quincozes-Santos Andre, Kauer-Sant`Anna Marcia and Kapczinski Flavio *, Neuron-glia Interaction as a Possible Pathophysiological Mechanism of Bipolar Disorder, Current Neuropharmacology 2018; 16 (5) . https://dx.doi.org/10.2174/1570159X15666170828170921
DOI https://dx.doi.org/10.2174/1570159X15666170828170921 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Dietary Regulation of Glucose Metabolism in Metabolic Syndrome
Current Vascular Pharmacology Mitochondria Damage in the Pathogenesis of Diabetic Retinopathy and in the Metabolic Memory Associated with its Continued Progression
Current Medicinal Chemistry Statins for the Prevention of First or Recurrent Stroke
Current Vascular Pharmacology Editorial: "Organic Compounds as Modulators of Oxidative Stress: Chemical and Biological Aspects"
Current Organic Chemistry Renal Venous Thrombosis in Neonates
Current Pediatric Reviews The Potential Role of Thiamine (Vitamin B1) in Diabetic Complications
Current Diabetes Reviews Prognostic Value of White Blood Cell Counts and C-reactive Protein in Acute Ischemic Stroke Patients After Intravenous Thrombolysis
Current Neurovascular Research Thrombin-Activatable Fibrinolysis Inhibitor
Current Medicinal Chemistry Role of CCK/Gastrin Receptors in Gastrointestinal/Metabolic Diseases and Results of Human Studies Using Gastrin/CCK Receptor Agonists/Antagonists in these Diseases
Current Topics in Medicinal Chemistry Susceptibility Factors for Early Reamputation in Diabetic Great Toe Gangrene
Current Diabetes Reviews The “Aged Garlic Extract” (AGE) and One of its Active Ingredients S-Allyl-LCysteine (SAC) as Potential Preventive and Therapeutic Agents for Alzheimer's Disease (AD)
Current Medicinal Chemistry Medico-Legal Issues with CTG Interpretation
Current Women`s Health Reviews The Effect of Drugs and Genetic Factors on the Development and Progression of the Atherosclerotic Process
Current Vascular Pharmacology HDL - Cholesterol: The New Target for Treatment
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Preeclampsia: Placental Origins, New Predictors and New Therapeutic Strategies
Current Women`s Health Reviews Antineovascular Agents in the Treatment of Eye Diseases
Current Pharmaceutical Design Complex Obesity
Current Pediatric Reviews Recent Updates on Novel Approaches in Insulin Drug Delivery: A Review of Challenges and Pharmaceutical Implications
Current Drug Targets Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects
Current Drug Metabolism The Novel Use of GLP-1 Analogue and Insulin Combination in Type 2 Diabetes Mellitus
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery