Abstract
Introduction: The Renin-Angiotensin System (RAS) has emerged as being related to vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer.
Objective: This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting enzymes (ACE and ACE2) as therapeutical targets for Malignant Epithelial Neoplasia, specifically for Oral Squamous Cell Carcinoma (OSCC).
Conclusion: The literature review and Bioinformatics analyses showed that ACE and ACE2 are interesting targets for OSCC treatment. Studies involving RAS and OSCC should be encouraged for experimental validation.
Keywords: Head and neck cancer, obesity, Angiogenesis, ACE, Ang 1-7, angiotensin-converting enzyme.
Protein & Peptide Letters
Title:Angiotensin-Converting Enzymes (ACE and ACE2) as Potential Targets for Malignant Epithelial Neoplasia: Review and Bioinformatics Analyses Focused in Oral Squamous Cell Carcinoma
Volume: 24 Issue: 9
Author(s): Carlos Alberto de Carvalho Fraga, Lucyana Conceicao Farias, Kimberly Marie Jones, Alfredo Mauricio Batista de Paula and Andre Luiz Sena Guimaraes*
Affiliation:
- Universidade Estadual de Montes Claros. Hospital Universitario Clemente Faria. Laboratorio de Pesquisa em Saude, 562 Av. Cula Mangabeira Santo Expedito. Montes Claros, MG,Brazil
Keywords: Head and neck cancer, obesity, Angiogenesis, ACE, Ang 1-7, angiotensin-converting enzyme.
Abstract: Introduction: The Renin-Angiotensin System (RAS) has emerged as being related to vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer.
Objective: This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting enzymes (ACE and ACE2) as therapeutical targets for Malignant Epithelial Neoplasia, specifically for Oral Squamous Cell Carcinoma (OSCC).
Conclusion: The literature review and Bioinformatics analyses showed that ACE and ACE2 are interesting targets for OSCC treatment. Studies involving RAS and OSCC should be encouraged for experimental validation.
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de Carvalho Fraga Alberto Carlos , Farias Conceicao Lucyana, Jones Marie Kimberly, Batista de Paula Mauricio Alfredo and Guimaraes Luiz Sena Andre *, Angiotensin-Converting Enzymes (ACE and ACE2) as Potential Targets for Malignant Epithelial Neoplasia: Review and Bioinformatics Analyses Focused in Oral Squamous Cell Carcinoma, Protein & Peptide Letters 2017; 24 (9) . https://dx.doi.org/10.2174/0929866524666170815161621
DOI https://dx.doi.org/10.2174/0929866524666170815161621 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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