A One-Pot Multicomponent Synthesis of Naphthoxazin-3-one Derivatives Using Amberlite IRA-400 Cl Resin as Green Catalyst

Title:A One-Pot Multicomponent Synthesis of Naphthoxazin-3-one Derivatives Using Amberlite IRA-400 Cl Resin as Green Catalyst

Volume: 15 Issue: 7

Author(s): Gurusamy Harichandran*, Parkunan Parameswari and Ponnusamy Shanmugam

Affiliation:

• Department of Polymer Science, University of Madras, Guindy Campus, Chennai 600 025,India

Keywords: Amberlite IRA-400 Cl resin, naphthoxazin-3-ones, solvent-free conditions, three-component reaction, green catalyst, therapeutic agents.

Abstract: An efficient Amberlite IRA-400 Cl resin catalyzed, solvent-free, one-pot synthesis of 1- aryl-1,2-dihydro-3H-naphtho[1,2-e][1,3]oxazin-3-ones via three-component reaction of arylaldehydes, urea, and β-naphthol are described. This method offers advantages such as easy work-up, low environmental impact, shortened reaction times, and high yields. The catalyst recovered was reused four times without significant loss of catalytic activity.

Cite this article as:

Harichandran Gurusamy*, Parameswari Parkunan and Shanmugam Ponnusamy , A One-Pot Multicomponent Synthesis of Naphthoxazin-3-one Derivatives Using Amberlite IRA-400 Cl Resin as Green Catalyst, Letters in Organic Chemistry 2018; 15 (7) . https://dx.doi.org/10.2174/1570178614666170811151040