Abstract
Background: All cancers are leading causes of morbidity and mortality worldwide. The urgent need for new lead compounds for the treatment of cancer is higher than ever before. Scientists search and try to discover effective but less harmful new anti-tumor agents. Surgery, chemotherapy and radiation are the bestknown methods for treating cancer, however, they continued to be limited. Rising efforts of the scientists toward success of the drug discovery is increasing. Indole ring is considered as a key molecule existing in various biologically active compounds. Indole derivatives are recognized to prevent proliferation and invasion of many cancer cells.
Conclusion: This review presents the existing status and the very recent studies of indoles which have promising activities such as derivatives of indole-3-carbinol, 3,3'-diindolylmethane (DIM), isatin etc. Their chemical and biological behavior as well as a general overview of the anticancer activity is discussed.
Keywords: Antioxidant, anticancer, carcinogenesis, DNA mutation, drug development, oxidative stress.
Current Organic Chemistry
Title:Recent Studies and Biological Aspects of Substantial Indole Derivatives with Anti-cancer Activity
Volume: 21 Issue: 20
Author(s): Sibel Suzen*
Affiliation:
- Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan-06100, Ankara,Turkey
Keywords: Antioxidant, anticancer, carcinogenesis, DNA mutation, drug development, oxidative stress.
Abstract: Background: All cancers are leading causes of morbidity and mortality worldwide. The urgent need for new lead compounds for the treatment of cancer is higher than ever before. Scientists search and try to discover effective but less harmful new anti-tumor agents. Surgery, chemotherapy and radiation are the bestknown methods for treating cancer, however, they continued to be limited. Rising efforts of the scientists toward success of the drug discovery is increasing. Indole ring is considered as a key molecule existing in various biologically active compounds. Indole derivatives are recognized to prevent proliferation and invasion of many cancer cells.
Conclusion: This review presents the existing status and the very recent studies of indoles which have promising activities such as derivatives of indole-3-carbinol, 3,3'-diindolylmethane (DIM), isatin etc. Their chemical and biological behavior as well as a general overview of the anticancer activity is discussed.
Export Options
About this article
Cite this article as:
Suzen Sibel *, Recent Studies and Biological Aspects of Substantial Indole Derivatives with Anti-cancer Activity, Current Organic Chemistry 2017; 21 (20) . https://dx.doi.org/10.2174/1385272821666170809143233
DOI https://dx.doi.org/10.2174/1385272821666170809143233 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy
Current Drug Targets Marine Natural Products and Related Compounds as Anticancer Agents: an Overview of their Clinical Status
Anti-Cancer Agents in Medicinal Chemistry The Multiple Layers of Signaling Selectivity at Protease-Activated Receptors
Current Pharmaceutical Design Radiation-Induced Extracranial Carotid Stenosis
Vascular Disease Prevention (Discontinued) Recent Patents on Live Bacteria and their Products as Potential Anticancer Agents
Recent Patents on Anti-Cancer Drug Discovery Active Targeted Drug Delivery for Microbes Using Nano-Carriers
Current Topics in Medicinal Chemistry Multiple VEGF Family Members are Simultaneously Expressed in Ovarian Cancer: a Proposed Model for Bevacizumab Resistance
Current Pharmaceutical Design Melatonin in the Biliary Tract and Liver: Health Implications
Current Pharmaceutical Design Novel Synthetic Pharmacophores Inducing a Stabilization of Cellular Microtubules
Current Cancer Drug Targets Pathophysiology of NASH: Perspectives for a Targeted Treatment
Current Pharmaceutical Design Estrogen-Related Receptors as Emerging Targets in Cancer and Metabolic Disorders
Current Topics in Medicinal Chemistry Oral Inflammation and Bacteremia: Implications for Chronic and Acute Systemic Diseases Involving Major Organs
Cardiovascular & Hematological Disorders-Drug Targets Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents
Current Medicinal Chemistry Advances in Vaccine Adjuvants For Infectious Diseases
Current HIV Research Valproic Acid As Anti-Cancer Drug
Current Pharmaceutical Design Chest Pain in Children
Current Pediatric Reviews Image-Guided Nanoparticle-Based siRNA Delivery for Cancer Therapy
Current Pharmaceutical Design Cancer Chemoprevention by Targeting the Epigenome
Current Drug Targets Preparation and Primary Bioevaluation of 99mTc-labeled-1-thio-β-D-Glucose as Melanoma Targeting Agent
Current Radiopharmaceuticals A Natural Membrane Vesicle Exosome-based Sinomenine Delivery Platform for Hepatic Carcinoma Therapy
Current Topics in Medicinal Chemistry