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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Inflammatory Biomarkers in Atrial Fibrillation

Author(s): Effimia Zacharia, Nikolaos Papageorgiou*, Adam Ioannou, Gerasimos Siasos, Spyridon Papaioannou, Manolis Vavuranakis, George Latsios, Charalampos Vlachopoulos, Konstantinos Toutouzas, Spyridon Deftereos, Rui Providência and Dimitris Tousoulis

Volume 26, Issue 5, 2019

Page: [837 - 854] Pages: 18

DOI: 10.2174/0929867324666170727103357

Price: $65

Abstract

During the last few years, a significant number of studies have attempted to clarify the underlying mechanisms that lead to the presentation of atrial fibrillation (AF). Inflammation is a key component of the pathophysiological processes that lead to the development of AF; the amplification of inflammatory pathways triggers AF, and, in tandem, AF increases the inflammatory state. Indeed, the plasma levels of several inflammatory biomarkers are elevated in patients with AF. In addition, the levels of specific inflammatory biomarkers may provide information regarding to the AF duration. Several small studies have assessed the role of anti-inflammatory treatment in atrial fibrillation but the results have been contradictory. Large-scale studies are needed to evaluate the role of inflammation in AF and whether anti-inflammatory medications should be routinely administered to patients with AF.

Keywords: Atrial fibrillation, inflammation, anti-inflammatory drugs, inflammatory biomarkers, C-reactive protein, interleukins, statins.

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