Abstract
Ursolic acid, a natural pentacyclic triterpenoid is commonly found in plants and foods with promising biological and pharmacological activities. The compound has been under the attention of researchers due to its considerable anticancer effects through suppression of differentiation, angiogenesis, invasion, and metastasis of tumor cells via different pathways with low toxicity. Bioavailability of ursolic acid is poor due to poor solubility of the compound in water. Low bioavailability and short plasma half-life of ursolic acid along with non-specific distribution in the body are considered as impediments in the therapeutic development of the compound. Nano-drug delivery systems may improve the pharmacokinetic, bioavailability, and therapeutic activity of some medicines. The present review has focused on recent developments regarding nano-drug delivery systems of ursolic acid in cancer therapy.
Keywords: Bioavailability, Cancer, Nanomedicine, Natural compounds, Ursolic acid, Review.
Current Medicinal Chemistry
Title:Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery
Volume: 25 Issue: 37
Author(s): Azadeh Manayi, Marjan Nikan, Navid Nobakht-Haghighi and Mohammad Abdollahi*
Affiliation:
- Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran,Iran
Keywords: Bioavailability, Cancer, Nanomedicine, Natural compounds, Ursolic acid, Review.
Abstract: Ursolic acid, a natural pentacyclic triterpenoid is commonly found in plants and foods with promising biological and pharmacological activities. The compound has been under the attention of researchers due to its considerable anticancer effects through suppression of differentiation, angiogenesis, invasion, and metastasis of tumor cells via different pathways with low toxicity. Bioavailability of ursolic acid is poor due to poor solubility of the compound in water. Low bioavailability and short plasma half-life of ursolic acid along with non-specific distribution in the body are considered as impediments in the therapeutic development of the compound. Nano-drug delivery systems may improve the pharmacokinetic, bioavailability, and therapeutic activity of some medicines. The present review has focused on recent developments regarding nano-drug delivery systems of ursolic acid in cancer therapy.
Export Options
About this article
Cite this article as:
Manayi Azadeh , Nikan Marjan , Nobakht-Haghighi Navid and Abdollahi Mohammad *, Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery, Current Medicinal Chemistry 2018; 25 (37) . https://dx.doi.org/10.2174/0929867324666170713102918
DOI https://dx.doi.org/10.2174/0929867324666170713102918 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Fusion of MLO and CC View Binary Patterns to Improve the Performance of Breast Cancer Diagnosis
Current Medical Imaging A Novel Highly Selective Cannabinoid CB2 Agonist Reduces in vitro Growth and TGF-beta Release of Human Glial Cell Tumors
Central Nervous System Agents in Medicinal Chemistry Synthesis, Computational Study, and Evaluation of In Vitro Antimicrobial, Antibiofilm, and Anticancer Activities of New Sulfanyl Aminonaphthoquinone Derivatives
Letters in Drug Design & Discovery Selective Estrogen Receptor Modulator Medicinal Chemistry At Merck. A Review
Current Topics in Medicinal Chemistry Antiangiogenic Function of Antithrombin is Dependent on its Conformational Variation: Implication for Other Serpins
Protein & Peptide Letters Editorial (Thematic Issue: Advances with microRNAs in Tumorigenesis and Cancer Therapy)
Current Pharmaceutical Design HPV Infection and Intraepithelial Lesions: Comparison Between HIVPositive and Negative Women
Current HIV Research Immunomodulatory Properties of Farnesoids: The New Steroids?
Current Medicinal Chemistry Osimertinib Quantitative and Gene Variation Analyses in Cerebrospinal Fluid and Plasma of a Non-small Cell Lung Cancer Patient with Leptomeningeal Metastases
Current Cancer Drug Targets An Overview of Chromatin-Regulating Proteins in Cells
Current Protein & Peptide Science Different Lifestyles in Young Women From Urban and Rural Areas May Explain Different Cardiovascular Risk
Vascular Disease Prevention (Discontinued) Retinoids as Therapeutic Agents: Today and Tomorrow
Mini-Reviews in Medicinal Chemistry Graphene and Graphene Oxide as a Docking Station for Modern Drug Delivery System
Current Drug Delivery Conjugation of Peptides to Antisense Interleukin-6 Via Click Chemistry
Current Medicinal Chemistry Ca2+ Mediates the Adhesion of Breast Cancer Cells in Self-Assembled Multifunctional Microfluidic Chip Prepared with Carbohydrate Beads
Micro and Nanosystems The Role of Diabetes in Molecular Pathogenesis of Cancer
Current Signal Transduction Therapy New Researches about Combinatorial Therapeutic Regimen on Cancer Treatment
Current Cancer Therapy Reviews Novel Biologics for the Treatment of Pediatric Severe Asthma
Current Respiratory Medicine Reviews Glioblastoma Tumor Initiating Cells: Therapeutic Strategies Targeting Apoptosis and MicroRNA Pathways
Current Molecular Medicine Meet Our Editorial Board Member
Current Cancer Therapy Reviews