Novel 11,12H-dihydronaphthalene[1,2-b]quinoline as Atypical Antipsychotic

Title:Novel 11,12H-dihydronaphthalene[1,2-b]quinoline as Atypical Antipsychotic

Volume: 15 Issue: 3

Author(s): Maria Matilde Ramirez Moran, Jorge Eduardo Angel Guio*, Natividad Herrera Cano, Biagina del Carmen Migliore, Rodolfo Izquierdo, Jaime Charris, Simon Lopez, Anita Israel, Ana Santiago, Roberto Rossi, Luis Perdomo, Akram Samear Dabian, Mariagracia Vera Sosa, Alejandra Villalba and Ligia Biagina Angel Migliore

Affiliation:

• Laboratorio de Sintesis Organica, Diseno y Evaluacion Farmacologica de Nuevos Productos, Departamento de Quimica, Facultad Experimental de Ciencias, Universidad del Zulia, Maracaibo,Venezuela

Keywords: Dopamine, schizophrenia, atypical antipsychotic, stereotypy, quinoline, molecular dynamics simulations.

Abstract: Background: Neurodegenerative, neurological and mental disorders, as well as substance abuse have a worldwide high incidence rate, becoming relevant factors that contribute to premature morbidity and mortality. Dopamine is well known to be involved in these pathologies. The key focus in the search for new drugs, that alleviate or cure these diseases, is pursuing the design of compounds with both efficacy and fewer adverse effects in order to obtain novel agents capable of restoring the homeostasis in the CNS of dopaminergic neurotransmission and counteracting some of neurodegenerative and neuropsychiatric diseases, such as Parkinson's disease, schizophrenia, Huntington's chorea and drug addictions.

Methods: the compounds 11,12H-dihydronaphthalene[1,2-b] quinoline 2a and 9-methoxy-11,12Hdihydronaphthalene [1,2-b] quinoline 2b were designed and synthesized. The organic synthesis was performed according to the outlined synthesis strategies, together with a pharmacological evaluation of the male Sprague-Dawley rats.

Results: Compound structures were confirmed by 1H, 13C, DEPT and HETCOR NMR. Pharmacological testing and computational studies validated the asserted medicinal-chemical approach for their design, showing compound 2a acting as an atypical dopamine antagonist.

Conclusion: The study showed that compound 2a has an atypical antagonistic action on the central dopaminergic system. These pharmacological and computational-theoretical results support the suitability of the medicinal chemical approach in the design of this compound.

Cite this article as:

Moran Matilde Ramirez Maria , Angel Guio Eduardo Jorge *, Cano Herrera Natividad , del Carmen Migliore Biagina , Izquierdo Rodolfo , Charris Jaime , Lopez Simon , Israel Anita , Santiago Ana , Rossi Roberto , Perdomo Luis , Dabian Samear Akram , Sosa Vera Mariagracia , Villalba Alejandra and Migliore Biagina Angel Ligia , Novel 11,12H-dihydronaphthalene[1,2-b]quinoline as Atypical Antipsychotic, Letters in Drug Design & Discovery 2018; 15 (3) . https://dx.doi.org/10.2174/1570180814666170704144246