Abstract
The current molecular understanding of Alzheimer’s disease (AD) has still not resulted in successful interventions. Mitochondrial dysfunction of the AD brain is currently emerging as a hallmark of this disease. One mitochondrial function often affected in AD is oxidative phosphorylation responsible for ATP production, but also for production of reactive oxygen species (ROS) and for the de novo synthesis of pyrimidines. This paper reviews the role of mitochondrial produced ROS and pyrimidines in the aetiology of AD and their proposed role in oxidative degeneration of macromolecules, synthesis of essential phospholipids and maintenance of mitochondrial viability in the AD brain.
Keywords: Mitochondria, DNA repair, dNTP pools, Nucleotide metabolism, Brain.
Current Medicinal Chemistry
Title:The Role of Mitochondrial Dysfunction in the Progression of Alzheimer’s Disease
Volume: 25 Issue: 40
Author(s): Claus Desler, Meryl S. Lillenes, Tone Tønjum and Lene Juel Rasmussen*
Affiliation:
- Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen,Denmark
Keywords: Mitochondria, DNA repair, dNTP pools, Nucleotide metabolism, Brain.
Abstract: The current molecular understanding of Alzheimer’s disease (AD) has still not resulted in successful interventions. Mitochondrial dysfunction of the AD brain is currently emerging as a hallmark of this disease. One mitochondrial function often affected in AD is oxidative phosphorylation responsible for ATP production, but also for production of reactive oxygen species (ROS) and for the de novo synthesis of pyrimidines. This paper reviews the role of mitochondrial produced ROS and pyrimidines in the aetiology of AD and their proposed role in oxidative degeneration of macromolecules, synthesis of essential phospholipids and maintenance of mitochondrial viability in the AD brain.
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Cite this article as:
Desler Claus , Lillenes S. Meryl , Tønjum Tone and Rasmussen Juel Lene*, The Role of Mitochondrial Dysfunction in the Progression of Alzheimer’s Disease, Current Medicinal Chemistry 2018; 25 (40) . https://dx.doi.org/10.2174/0929867324666170616110111
DOI https://dx.doi.org/10.2174/0929867324666170616110111 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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