Abstract
Liquid chromatography (LC) coupled to an electrochemical (EC) detector is a complementary analytical tool compared to LC coupled with optical or mass spectrometry detectors (LC-MS). LC-EC can be applied to the determination of molecules difficult to be analyzed by other commercially available detectors. New EC detector design and new working electrode material have extended the scope of application in the field of pharmaceutical compounds analysis. Combining EC with LC-MS offers additional advantages compared to optical detectors in terms of drug stability and drug metabolism mimicry studies. Selected literature devoted to pharmacologically active compounds in their dosage forms, herbal drugs in natural products, drug residues in feed and/or in biological samples are reported in this review.
Keywords: Liquid chromatography, electrochemical detector, biomedical, pharmaceutical analysis, bioanalysis, amperometry.
Current Medicinal Chemistry
Title:Electrochemical Detectors in Liquid Chromatography: Recent Trends in Pharmaceutical and Biomedical Analysis
Volume: 25 Issue: 33
Author(s): Jean-Michel Kauffmann*, Nurgul K. Bakirhan, Burcin Bozal-Palabiyik, Bengi Uslu, Rocio Rodriguez Gomez, Marie Vandeput and Sibel A. Ozkan
Affiliation:
- Universite Libre de Bruxelles (ULB), Faculty of Pharmacy, Campus Plaine CP 205/6, 1050 Brussels,Belgium
Keywords: Liquid chromatography, electrochemical detector, biomedical, pharmaceutical analysis, bioanalysis, amperometry.
Abstract: Liquid chromatography (LC) coupled to an electrochemical (EC) detector is a complementary analytical tool compared to LC coupled with optical or mass spectrometry detectors (LC-MS). LC-EC can be applied to the determination of molecules difficult to be analyzed by other commercially available detectors. New EC detector design and new working electrode material have extended the scope of application in the field of pharmaceutical compounds analysis. Combining EC with LC-MS offers additional advantages compared to optical detectors in terms of drug stability and drug metabolism mimicry studies. Selected literature devoted to pharmacologically active compounds in their dosage forms, herbal drugs in natural products, drug residues in feed and/or in biological samples are reported in this review.
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Cite this article as:
Kauffmann Jean-Michel *, Bakirhan K. Nurgul , Bozal-Palabiyik Burcin, Uslu Bengi , Rodriguez Gomez Rocio, Vandeput Marie and A. Ozkan Sibel , Electrochemical Detectors in Liquid Chromatography: Recent Trends in Pharmaceutical and Biomedical Analysis, Current Medicinal Chemistry 2018; 25 (33) . https://dx.doi.org/10.2174/0929867324666170609074826
DOI https://dx.doi.org/10.2174/0929867324666170609074826 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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