Abstract
Background: Biomarkers are indispensable tools for screening, diagnosis, and prognosis in cardiovascular diseases and their clinical application increases steadily. As cardiovascular diseases include various pathophysiological processes, no single biomarker, even natriuretic peptides, can be regarded as ideal fulfilling all necessary criteria for a comprehensive diagnostic or prognostic assessment revealing optimal clinical application. Hence, multi-marker approaches using different biomarkers reflecting different pathophysiologies were highlighted recently. Advances in biomedical technologies expanded the spectrum of novel blood-derived biomarkers, such as micro-RNA (miRNA) or “omics”- data potentially providing a more advanced knowledge about pathogenesis of cardiovascular disease.
Conclusion: This review describes the advantages and limitations of blood circulating biomarkers with regard to proteins, metabolomics and transcriptional level both within single as well as multi-marker strategies. Moreover, their usefulness is focused on clinical decision-making in cardiovascular diseases.Keywords: Cardiovascular disease, heart failure, acute coronary syndrome, biomarker, proteome, metabolome, micro-RNA.
Current Pharmaceutical Biotechnology
Title:Advantages and Limitations of Current Biomarker Research: From Experimental Research to Clinical Application
Volume: 18 Issue: 6
Author(s): Seung-Hyun Kim *, Christel Weiß , Ursula Hoffmann, Martin Borggrefe, Ibrahim Akin and Michael Behnes
Affiliation:
- First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim,Germany
Keywords: Cardiovascular disease, heart failure, acute coronary syndrome, biomarker, proteome, metabolome, micro-RNA.
Abstract: Background: Biomarkers are indispensable tools for screening, diagnosis, and prognosis in cardiovascular diseases and their clinical application increases steadily. As cardiovascular diseases include various pathophysiological processes, no single biomarker, even natriuretic peptides, can be regarded as ideal fulfilling all necessary criteria for a comprehensive diagnostic or prognostic assessment revealing optimal clinical application. Hence, multi-marker approaches using different biomarkers reflecting different pathophysiologies were highlighted recently. Advances in biomedical technologies expanded the spectrum of novel blood-derived biomarkers, such as micro-RNA (miRNA) or “omics”- data potentially providing a more advanced knowledge about pathogenesis of cardiovascular disease.
Conclusion: This review describes the advantages and limitations of blood circulating biomarkers with regard to proteins, metabolomics and transcriptional level both within single as well as multi-marker strategies. Moreover, their usefulness is focused on clinical decision-making in cardiovascular diseases.Export Options
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Cite this article as:
Kim Seung-Hyun *, Weiß Christel , Hoffmann Ursula, Borggrefe Martin , Akin Ibrahim and Behnes Michael , Advantages and Limitations of Current Biomarker Research: From Experimental Research to Clinical Application, Current Pharmaceutical Biotechnology 2017; 18 (6) . https://dx.doi.org/10.2174/1389201018666170601091205
DOI https://dx.doi.org/10.2174/1389201018666170601091205 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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