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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Research Article

Pd/C-catalyzed Synthesis of 4-biaryl Substituted 2-amino benzo[h] chromene Derivatives as Potential Cytotoxic Agents

Author(s): Chekuri Sharmila Rani, Meda Haritha, Mandava V. Basaveswara Rao* and Manojit Pal*

Volume 15, Issue 2, 2018

Page: [160 - 168] Pages: 9

DOI: 10.2174/1570180814666170530094023

Price: $65

Abstract

Background: We report the design, synthesis and evaluation of a series of 4-biaryl substituted 2-amino benzo[h]chromene derivatives as potential cytotoxic agents.

Methods: The one-pot synthesis of this class of compounds was carried out under ultrasound irradiation using an MCR involving Pd/C-catalyzed Suzuki-Miyaura coupling as a key step.

Result and Conclusion: Several of these compounds showed promising cytotoxicities when tested against cancer cell lines but no or little effects on non-cancerous cell lines.

Keywords: 2-amino benzo[h]chromene, MCR, Pd/C, cytotoxicity, cytotoxic agents, potential treatment.

Graphical Abstract

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