Background: Acquired hemophilia is a rare bleeding disease which might be associated
with some autoimmune diseases. Acquired hemophilia may be the result of autoantibodies against
Case Presentation: In this study, we describe a 55 year old patient who developed hematoma and
hematuria due to acquired hemophilia secondary to systemic lupus erythematosus (SLE). Then, she
developed arthritis and thrombosis after some evaluations. Laboratory data showed prolonged
aPTT, normal PT and platelet, low FVIII, high FVIII inhibitor, ANA, anti-ds-DNA, and anticardiolipin.
This patient was treated with corticosteroids, FEIBA and rituximab, so she recovered
and was discharged about seven days later.
Conclusion: We should consider lupus erythematosus in patients with acquired hemophilia. Some
cases of acquired hemophilia may be an SLE manifestation, so we should consider this situation to
diagnose the disease properly.