Abstract
Background: Thioureas are widely used as intermediates in organic synthesis, and they are commonly used in several classes of heterocycles.
Objective: There has been an escalating interest in the development of heterocycles employing thioureas as building blocks. Furthermore, thioureas can be utilized as a reagent in a synthesis of a large number of therapeutic agents. In addition, substituted thioureas have recently gained much interest in the preparation of a wide variety of biologically active compounds.
Conclusion: This review highlights the status of thiourea scaffolds in the drug development and heterocyclic synthesis described in the literature mainly since 2010.
Keywords: Thiourea, heterocyclic synthesis, building blocks, drug design, pharmacological effects, multicomponent reactions.
Mini-Reviews in Organic Chemistry
Title:Thioureas as Building Blocks for the Generation of Heterocycles and Compounds with Pharmacological Activity: An Overview
Volume: 15 Issue: 1
Author(s): Itamar Luís Goncalves, Gabriel Oliveira de Azambuja, Daniel Fabio Kawano and Vera Lucia Eifler-Lima*
Affiliation:
- Laboratorio de Sintese Organica Medicinal/LaSOM, Programa de Pos-Graduacao em Ciencias Farmaceuticas/ PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS,Brazil
Keywords: Thiourea, heterocyclic synthesis, building blocks, drug design, pharmacological effects, multicomponent reactions.
Abstract: Background: Thioureas are widely used as intermediates in organic synthesis, and they are commonly used in several classes of heterocycles.
Objective: There has been an escalating interest in the development of heterocycles employing thioureas as building blocks. Furthermore, thioureas can be utilized as a reagent in a synthesis of a large number of therapeutic agents. In addition, substituted thioureas have recently gained much interest in the preparation of a wide variety of biologically active compounds.
Conclusion: This review highlights the status of thiourea scaffolds in the drug development and heterocyclic synthesis described in the literature mainly since 2010.
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Goncalves Luís Itamar , de Azambuja Oliveira Gabriel , Kawano Fabio Daniel and Eifler-Lima Lucia Vera*, Thioureas as Building Blocks for the Generation of Heterocycles and Compounds with Pharmacological Activity: An Overview, Mini-Reviews in Organic Chemistry 2018; 15 (1) . https://dx.doi.org/10.2174/1570193X14666170518125219
DOI https://dx.doi.org/10.2174/1570193X14666170518125219 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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