Abstract
Background: The incorporation of selenium (Se) atom onto organic scaffolds is a very promising approach to obtain more active and selective compounds against several types of cancer. During the last decade, a plethora of organoselenium compounds have been reported with very potent anticancer activity through diverse mechanisms of action, some of the most interesting being autophagy, angiogenesis, affectation of cancer stem cells and lethal mitosis. Several studies have related Se status and different selenoproteins with the development of Leishmania. Furthermore, one of the most used approaches for seeking new antitrypanosomal drugs is the drug repositioning. Considering both facts, our research group is developing organoselenium derivatives with dual activity against cancer and Leishmaniasis.
Objective: The objective of this review is to gather, for the first time, every organic selenocompound with this dual activity. Thereby, the synthetic procedures will be discussed, along with their most important biological effects in both pathologies.
Conclusion: To conclude, the reported results show that the introduction of Se atom onto organic molecules is a valid rational approach to obtain dual anticancer/leishmanicidal agents. Furthermore, the synthetic procedures needed are quite straightforward and occur with good yields. Thus, bisacylimidoselenocarbamates and diselenides are very good candidates to further develop as dual agents.
Keywords: Biological activity, bisacylimidoselenocarbamates, cancer, diselenides, dual activity, leishmanial, selenium, synthesis.
Graphical Abstract
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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